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Relationship between serum Iron、Ferritin and lipid peroxidation injury in patients with chronic hepatitis B.
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摘要: 目的探讨慢性乙型肝炎（CHB）患者血清铁（SI）、铁蛋白（SF）水平与脂质过氧化损伤的关系。方法选择79例CHB患者,用比色法测SI、放射免疫法测SF、硫代巴比妥酸法测丙二醛（MDA）、黄嘌呤氧化酶法测超氧化物歧化酶（SOD）。结果各组CHB患者SI、SF和MDA水平均高于对照组（P<0.050.01）,SOD水平均低于对照组（P<0.01）。79例CHB患者SI、FE水平与MDA水平均正相关（r=0.493,P<0.01;r=0.745,P<0.01）;SI水平与SOD水平负相关（r=-0.27,P<0.05）。结论CHB患者SI、SF水平与脂质过氧化损伤有相关性,过重的铁负荷协同乙肝病毒加重肝损伤。Abstract: Objective To investigate the relationship between serum iron (SI) , serum ferritin (SF) and lipid peroxidation injury in patients with chronic hepatitis B.Methods 79 patients with chronic hepatitis B were enrolled in this study.SI was detected by chromatometry, SF by Radio-immunity, MDA by thiobarbituric acid method, and SOD by xanthineoxidase method.Results Compared to control group, the level of SI, FE and MDA in patients with chronic hepatitis B were higher significantly (P<0.05-0.01) .On the contrary, the level of SOD in patients with chronic hepatitis B was lower significantly (P<0.01) .In 79 patients with chronic hepatitis B, correlation analyses found that SI and FE were in positive correlation with MDA (r=0.493, P<0.01, r=0.745, P<0.01) , and SI was in negative correlation with SOD (r=-0.27, P<0.05) .Conclusion The levels of SI and SF in patients with chronic hepatitis B are closely related to lipid peroxidation injury, and the overload of iron may enhance the hepatocytes damage induced by HBV.
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Key words:
- hepatitis B /
- serum iron /
- serum ferritin /
- lipid peroxidation /
- malondialdehyde
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