门脉高压胃病与前列环素I2的关系

张初民; 韩盛玺

门脉高压胃病与前列环素I2的关系

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中图分类号: R573
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出版历程
- 出版日期: 2008-01-20

The relationship between plasma prostaglandin I2 and portal hypertensive gastropathy in patients with cirrhosis.

摘要

摘要: 目的了解血浆前列环素在肝硬化门脉高压性胃病发病中的作用。方法应用特异性放射免疫分析法测定49例肝硬化门脉高压性胃病患者及30例正常对照者血浆前列环素水平。结果49例肝硬化门脉高压性胃病患者前列环素水平(137.31±61.82)pg/ml明显高于对照组(89.6±22.6)pg/ml,(t=1.684,P<0.05)。其中门脉高压性胃病轻、中度患者与对照组比较,均有明显差异(t=1.725,t=1.853,P<0.05),门脉高压性胃病重度患者与对照组比较,差异更明显(t=2.117,P<0.025)。但门脉高压性胃病各级间比较均无明显差异(P>0.05)。结论肝硬化门脉高压性胃病患者血浆前列环素明显升高,作为具有扩血管作用的炎性介质,在门脉高压性胃病发病中起重要作用。
- 肝硬化 /
- 门脉高压性胃病 /
- 前列环素 /
- 放射免疫分析法
Abstract: Objective To evaluate the role of plasma prostaglandin I2 (PGI2) in the development portal hypertensive gastropathy (PHG) in patients with liver cirrhosis.Methods Plasma prostaglandin I2 concentration was measured by radioimmunoassay in 49 patients with PHG and 30 healthy controls.Results Plasma PGI2 levels were significantly increased in patients with mild、middle and severe PHG compared to healthy controls (137.31±61.82) pg/ml VS (89.6±22.6) pg/ml, t=1.684, P<0.05) .Conclusion The level of plasma PGI2 was shown to be increased in cirrhotic patients accompany PHG, Supporting that its syrtthesis by blood vessels of systemic circulation is enhanced.PGI2 as an inflammatory medium, damages the gastric mucosa by expanding vessels in PHG.
- liver cirrhosis /
- portal hypertensive gastropathy /
- Prostaglandin I2 /
- radioimmunoassay

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参考文献(6)

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