Smad7对TGF-β/SMAD的调节及其在肝纤维化中的作用

杨小艳; 郑勇

Smad7对TGF-β/SMAD的调节及其在肝纤维化中的作用

杨小艳,
郑勇

基金项目:

兵团博士基金课题(O5JC08)；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 出版日期: 2007-06-20

Research funding:

摘要

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参考文献(19)

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[6]Heldin CH, Miyazono K, Dijke PT, et al.TGF-βsignaling fromcell membrane to nucleus through SMAD proteins[J].Nature, 1997, 390 (6659) ∶465-471.

[7]Dooley S, Delvoux B, Streckert M, et al.Transforming growth factorbeta signal transduction in hepatic stellate cells via Smad2/3 phos-phorylation, a pathway that is abrogated during in vitro progression tomyofibroblasts[J].FEBS Lett, 2001, 502 (1-2) ∶4-10.

[8]Schiffer M, Von Gersdorff G, Bitzer M, et al.Smad proteins andtransforming growth factor beta signaling[J].Kidney Int, 2000, 77∶S45-S52.

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[10]周朝晖, 蔡瑜, 沈锡中, 等.甘草酸对四氯化碳肝纤维化大鼠肝组织smad2免疫组织化学表达的影响[J].肝脏, 2006, 11 (1) ∶35-36.

[11]Dooley S, Hamzavi J, BreitkopfK, et al.Smad7 prevents activationof hepatic stellate cells and liver fibrosis in rats[J].Gastroenterolo-gy, 2003, 125 (1) ∶178-91.

[12]陈颖伟, 陈源文, 尤汉宁, 等.外源Smad7基因对原代肝星状细胞活性和基因表达调控的影响[J].中华消化杂志, 2005, 25 (7) ∶409-412.

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[15]李瑾, 王宁宁, 谭若云, 等.Smad信号传递途径调节肾小管上皮细胞转分化实验[J].肾脏病与透析肾移植杂志, 2005, 14 (3) ∶230-233.

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[17]Chun-rong JU, Xi-zheng XIA.The expression of Smad7 in therats with pulmonary interstitial fibrosis and the therapeutic effect of IL-7[J].Int J Respir, 2006, 26 (7) ∶486-489.

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