肝素抗肝纤维化作用机制及临床疗效评价

石军; 郝菁华; 朱菊人; 任万华

肝素抗肝纤维化作用机制及临床疗效评价

基金项目:

山东省卫生厅资助(CA2CKA2号)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2006-03-20

The mechanism of heparin on liver fibrosis and the evaluation of effects in clinic.

Research funding:

摘要

摘要: 探讨肝素对慢性乙型肝炎患者肝纤维化的影响及作用机制。将63例慢性乙型肝炎患者随机分为A（26例）、B（37例）两组,分别给予常规药物治疗和肝素治疗。治疗前后分别检测血清丙氨酸转氨酶（ALT）、总胆红素（TB il）、透明质酸（HA）、Ⅳ型胶原（CⅣ）和转化生长因子-β1（TGF-β1）、血管性假性血友病因子（vWF）水平。B组中6例分别于治疗前后行肝活检术。治疗后A、B两组的ALT、TB il水平均显著下降。B组治疗后HA、CⅣ、TGF-β1及vWF水平均显著下降,而A组HA、CⅣ水平反较治疗前升高,TGF-β1及vWF水平无明显变化。B组治疗后肝组织原纤维增生减轻,肝星状细胞恢复正常。肝素通过抑制肝星状细胞活化和改善肝脏微循环达到抗纤维化的目的。
- 乙型肝炎 /
- 肝纤维化 /
- 肝素
Abstract: The study was aimed to evaluate the effects of heparin on liver fibrosis in patients with chronic hepatitis B.Sixty-three cases under study were divided into two groups, group A and group B.The two groups were given regular treatment and heparin treatment respectively.Serum ALT and TBil, hyaluronate (HA) , Ⅳ-type collagen (Ⅳ-C) , transforming grouth factor-β1 (TGF-β1) and plasma vWF levels were measured before and after the treatment.Six cases of group B were taken liver biopsy twice.After treatment, hepatic functions became significantly improved in both groups.Serum HA and Ⅳ-type collagen, TGF-β1 levels and plasma vWF levels in group B decreased significantly after treatment while serum HA and Ⅳ-type collagen levels elevated in group A.Serum TGF-β1 and plasma vWF levels in group A changed not much.Collagen proliferation lessened in group B after treatment.Hepatic stellet cells turned normal.Heparin can inhibit liver fibrosis by inhibiting the activation of hepatic stellet cells and improving hepatic microcirculation.
- hepatitis B /
- liver fibrosis /
- heparin

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参考文献(5)

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