HBV感染对原发性肝细胞癌生物学行为及p53蛋白的表达影响

闵婕; 冯英明; 张贺龙; 姬统理; 李刚

HBV感染对原发性肝细胞癌生物学行为及p53蛋白的表达影响

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中图分类号: R735.7
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出版历程
- 出版日期: 2006-02-20

Influence of HBV inflection on biological behaviours of hepatocellular carcinoma (HCC) and expression of p53 protein.

摘要

摘要: 探讨在原发性肝细胞癌（HCC）中乙型肝炎病毒（HBV）的感染对肿瘤生物学行为以及突变型p53蛋白的表达影响。利用血清学指标检测60例HCC的HBV感染情况,采用抗生蛋白链霉素-过氧化酶法（S-P）检测癌组织中突变p53蛋白的表达。38例HBV感染HCC中突变p53蛋白的表达率为73.68%（28/38）,22例非HBV感染表达率为45.45%（10/22）,两者有显著差异（P<0.05）。在HCC中,HBV感染与肿瘤的Edmondson分级、AFP值增高、门静脉癌栓形成、肝内转移以及转氨酶增高相关（P<0.05）。HBV的感染可能与p53基因的突变共同作用导致HCC的发生及发展。同时检测以上二种指标可以为认识HCC的生物学特性,制定合理的综合治疗方案提供依据。
- 肝癌 /
- 乙型肝炎病毒
Abstract: To study the influences of HBV infection on biological behaviours of hepatocellular carcinoma (HCC) and expression of mutate p53 protein.The state of HBV inflection were determined by serum tests for 60 patients with hepatocellular carcinoma.Meanwhile, expression of mutated p53 protein carcinoma tissues were detected by using hepatocellular streptavidin-peroxidase (S-P) method.The expression rate (73.68% (28/38) ) of 38 cases of patients carcinoma infected by HBV with hepatocellular was significantly higher than that (45.45% (10/22) ) of 22 cases of patients with hepatocellular carcinoma not infected by HBV (P<0.05) Among the patients with HCC, The patients with hepatocellular carcinoma being detected, the statas of HBV infection is positively correlations with Edmondson grades, the elevation of serum α-fectoprotein (AFP) levels, intraportal carcinoma embolism, intrahepatic metastasis, and elevation of serum aminotransferase (P<0.05) .The state of HBV infection may join the mutation of p53 protein in the occurrence and development of hepatocellular carcinoma.To detect them helps us to learn the biological traits of hepatocellular carcinoma and to design the medicine plans.
- hepatocellular carcinoma /
- hepatitis B virus (HBV)

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参考文献(10)

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