PDF下载 ( 121 KB)
Relationship between clinics and the content of serum HBV DNA in different clinical types of chronic hepatitis B.
-
摘要: 探讨不同类型慢性乙型肝炎 (慢乙肝 )患者病毒复制水平与肝损害程度的关系。 180例慢乙肝患者血清HBVDNA基因含量采用荧光定量PCR方法检测。血清HBeAg阳性组HBVDNA含量 (10 6 3 5± 1 84)显著高于HBeAg阴性组 (10 4 73± 1 88) (P <0 0 1) ,不同类型慢乙肝组血清HBVDNA含量相比较无显著性差异 (P >0 0 5 )。研究证实 ,血清HBeAg的存在影响HBVDNA的水平变化 ,不同类型慢性乙型肝炎肝损害程度与血清HBVDNA基因含量无明显关系Abstract: To explore the relationship between the nucleic acid content of hepatitis B virus and liver function or its pathological state of patients with different clinical types of chronic hepatitis B. Fluorescence quantitative PCR was used to measure the HBV DNA in 180 cases. The HBV DNA content in the group of HBeAg positive (10 6.35±1.84) was significantly higher than that of HBeAg negative (10 4.73±1.88) (P<0.01) . There were not significant difference between HBV DNA content and different clinical types of chronic hepatitis B (P>0.05) . There is a significant correlation between HBeAg and HBV DNA, but not between liver inflammation stage and serum HBV DNA content in different clinical types of chronic hepatitis B.
-
Key words:
- chronic hepatitis B /
- HBV DNA /
- fluorescence quantitative PCR
-
[1]蔡卫平, 唐小平, 陈劲峰, 等.慢性乙型肝炎HBV -DNA定量检测与病原学标志和肝损害程度的关系[J].中国实用内科杂志, 1998, 18 (3) ∶149-150. [2]张复春, 吴婉芬, 董惠卿, 等.定量聚合酶链反应检测血清中HBVDNA及其临床应用[J].中华传染病杂志, 1997, 15 (1) ∶24-27. [3]张玲, 朱江华, 马韵, 等.乙型肝炎病毒核酸定量检测与临床的关系[J].中华肝脏病杂志, 2002, 10 (1) ∶49-51. [4]程钢, 何蕴韶, 周新宇.荧光定量聚合酶链反应检测乙型肝炎病毒[J].中华医学检验杂志, 1999, 22 (3) ∶135-138. [5]中华医学会传染病与寄生虫病学分会、肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) ∶324-329. [6]王虹, 万成松, 王省良, 等.乙型肝炎患者HBVDNA定量测定与临床疗效的关系[J].中华肝脏病杂志, 2000, 8 (4) ∶255. [7]刘宝芳, 席志宾.各型乙型肝炎患者血液HBVDNA水平与临床的关系[J].中华肝脏病杂志, 2002, 10 (1) ∶65. [8]周小辉, 周元平, 姚春兰, 等.慢性乙型肝炎患者血清HBVDNA含量与肝细胞损伤程度的关系[J].中华肝脏病杂志, 1999, 7 (3) ∶167. -
本文二维码
计量
- 文章访问数: 2475
- HTML全文浏览量: 14
- PDF下载量: 1057
- 被引次数: 0
下载:
