肝内胆管癌细胞9810凋亡和bcl-2基因表达关系研究

夏光涛; 张尚忠; 史朝晖

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肝内胆管癌细胞9810凋亡和bcl-2基因表达关系研究

详细信息

中图分类号: R735.8
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出版历程
- 出版日期: 2004-03-20

Study of the relation between the apoptosis of intrahepatic cholangiocarcinoma cell lines 9810 and expression of bcl-2 gene

摘要

摘要: 应用阿霉素诱导肝内胆管癌细胞 9810凋亡 ,研究其凋亡与bcl- 2基因表达之间的关系。应用流式细胞仪检测肝内胆管癌细胞凋亡的情况 ,并同时检测bcl- 2基因表达。随着阿霉素浓度的增加 ,细胞凋亡率逐步上升 ,同时bcl- 2基因表达下调。bcl- 2基因表达下调是阿霉素诱导肝内胆管癌细胞凋亡机制之一。
- 肝内胆管癌 /
- 阿霉素 /
- 凋亡 /
- bcl-2基因
Abstract: To investigate the relation between apoptosis of intrahepatic cholangiocarcinoma cell lines 9810 and expression of bcl-2 gene. We detect its apoptosis and expression of bcl-2 gene by flow cytometer. Apoptosis of intrahepatic cholangiocarcinoma was up step by step flowing Adriacin's concentration, expression of bcl-2 gene was down as well as it. Influencing expression of bcl-2 gene may be a reason of apoptosis of intrahepatic cholangiocarcinoma cell.
- intrahepatic cholangiocarcinoma /
- Adriacin /
- apoptosis /
- bcl-2 gene

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参考文献(3)

[1]何振平.肝内胆管癌的临床病理特征、诊断及治疗[J].中国普外基础与临床杂志, 2001, 8 (2) ∶125-127.

[2]金凯, 叶山仰.肝内胆管癌24例[J].浙江肿瘤, 1998, 4 (2) ∶121.

[3] OkaroAC , FennellDA , CorboM , etal.Pk11195, amitochondrialben zodiazepinereceptorantagonist, reducesapoptosisthresholdinBcl-X (L) andMcl-1expressinghumancholangiocarcinomacells.Gut, 2002, 51 (4) ∶556-61.

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