慢性乙肝患者血清sICAM-1与IL-18的变化及相关性研究

刘家秀; 史亚明; 黄加忠; 姜玉章; 朱礼尧; 汪习成

慢性乙肝患者血清sICAM-1与IL-18的变化及相关性研究

基金项目:

淮安市自然科技资金资助；

详细信息

中图分类号: R512.62
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出版历程
- 出版日期: 2003-04-20

Study on relationship between sICAM-1、IL-18 level changes in sera of the patients with chronic hepatitis B

Research funding:

摘要

摘要: 检测慢性乙型肝炎（CHB）患者血清可溶性细胞间粘附分子 - 1（sICAM - 1）、白细胞介素 18（IL - 18）水平 ,探讨sICAM - 1、IL - 18变化规律及临床意义。采用ELISA法对慢性乙型肝炎患者血清sICAM - 1、IL - 18水平进行测定。慢性乙型肝炎患者血清sICAM - 1、IL - 18水平明显高于健康对照组 ;且二者呈正相关。sICAM - 1、IL - 18可能参与慢性肝炎的损伤过程
- 慢性乙型肝炎 /
- 血清可溶性细胞间粘附分子-1 /
- IL-18
Abstract: To investigate the changes and clinical significances of serum sICAM-1 and IL-18 levels in the patients with chronic hepatitis B. The sICAM-1 and IL-18 levels in serum of the patients with chronic hepatitis B were detected by ELISA. The sICAM-1 and IL-18 levels were significantly higher than those of healthy groups. Moreover, there was a close positive correlation between sICAM-1 and IL-18. The sICAM-1 and IL-18 may participate in liver inflammatory injury process.
- Chronic hepatitis B /
- sICAM-1 /
- IL-18

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参考文献(7)

[1]DoiT , YamadaG , MizunoM , etal.Immunohistochemicalstudyofthedistributionofintercellularadhesionmolecule-1andlymphocytefunction-associatedantigen-1inchronictypeBhepatitis[J].JGastroenten terol, 1994, 29∶164-171.

[2]MaliziaG , Dino0, PisaR , etal.ExpressionofleukocyteadhesionmoleculesintheliverofpatientswithchronichepatitisBvirusinfection[J].Gastroenterol, 1991, 100∶749.

[3]HirokoTsutsui, KiyoshiMatsui, HarukiOkamura, etal.Pathophysiolog icalrolesofinterleukin-18ininflammatoryliverdiseases[J].Immuno logicalReviews2000Vol.174∶192-209.

[4]病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) ∶324-329.

[5]DaoT , OhashiK , KayanoT , etal.Interferon-rinducingfactor, anov elcylokine, enhancesFasligandmediatedcytotoxiicityofmurineThelperlcell[J].CellImmunol, 1996, 173∶230.

[6]TsutsuiH , KayagakiN , KuidaK , etal.Caspase-1-indendent, Fasfasligand-mediatedIL -18secretionfrommacrophagescausesacuteliverinjuryinmice[J].Immunity, 1999, 11 (3) ∶359-67.

[7]潘红英.IL -18与肝损伤机理研究进展[J].浙江医学, 2000, 22 (11) ∶702-703

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