Abstract: To investigate the etiology of chronic hepatitis B (HB) post cirrhosis gastritic mucosal lesion.In 102 patients diagnostic endoscopy was performed.Three gastric biopsies were taken within 2-3cm around the pylorus of gastric antra, urease detection, HE fuchsin staining and immunohistochemical analysis of Helicobacter pylori (HP) IgG antigen, HBsAg and HBcAg were performed separately.In cirrhosis group, 95.5% of 44 patients (42/44) showed different extent of chronic inflammation of gastric mucosa 92.9% (26/28) in chronic hepatitis B group.In addition to chronic gastric mucous inflammation, the date of existence of gland atrophy or/and intestinal epithelialization is 33.3% (14/42) and 11.5% (3/26) respectively (P<0.05) .The positivity of HBVAg in these two groups is 81.8% (36/44) and 53.6% (15/28) respectively (P<0.05) .In these two groups the positive rate of HP in inflammatory gastric mucous is 69.0% (29/42) and 76.9% (20/26) respecctively, there is no obvious defference between them. Among the 42 patients with cirrhosis associated gastritis, 19 were found to be esophageales varicosis positive, but the other 23 were not, the positivity of HP of these two groups was 73.7% (14/19) and 65.3% (15/23) (P>0.05) .The result of analysis of the severity of HB associated gastritis indicated that the portal hypertensive cirrhosis in later stage of liver disease plays an important role in the development of this disease.The relationship between hepatitis B virus and this disease needs further investigation.HP is not the pathogeny of this disease.