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Expression of CD86 in chronic hepatitis and human Hepatoma
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摘要: 探讨慢性肝炎及肝细胞肝癌组织中CD86表达与临床的关系。采用免疫荧光方法检测 10 0例慢性肝炎及肝细胞肝癌组织中CD86的表达。肝癌组织中肝细胞CD86表达明显低于肝炎组织。CD86表达缺失可引起肝癌细胞的免疫逃逸Abstract: To investigate the expression and clinical significance of CD86 in chronic hepatitis and hepatoma. The specimens of 100 cases were examined by immunofluorescence. CD86 expression in the hepatitis occurred more frequently than that in hepatoma. ( P<0 005) . The deletion of CD86 in malignant hepatocytes can cause its immune sneaking through.
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Key words:
- Chronic Hepatitis /
- Hepatoma /
- CD86
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[1]Schwartz RH. A cell culture model for T lymphocyte clonal anergy[J].Science, 1990, 248 (4961) ∶1349-1356. [2]Leideld L, Trantwein C, Dumoulin FL, et al. Enhanced expression of CD80, CD86 and CD40 and their ligands CD28 and CD154 in fulminant hepatitis failure[J].Am J Pothol, 1999, 154 (6) ∶1711-1720. [3]June CH, Bluesyone JA, Nadler LM, et al. The B7 and CD28 receptor families[J].Immunol Today, 1994, 15 (7) ∶321-331. [4]Felzmann T, William JR, Michael Blaese R. Anti-tumor immunity generated by tumor cells engineered to express B7-1 via retrovial or adenoviral gene transfer[J].Cancer Letters, 1999, (135) ∶1-10. -
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