IFN-α对慢性乙肝肝纤维化阻断作用的研究

孔丽; 李兵顺; 任仲轩; 胡云龙; 刘金星

IFN-α对慢性乙肝肝纤维化阻断作用的研究

基金项目:

河北省科技攻关计划项目 ;项目号 (992 761178)；

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2002-06-20

The study of inhibitory effect of IFN-α therapy for hepatic fibrosis in patients with chronic hepatitis B

Research funding:

摘要

摘要: 探讨IFN -α对慢性乙肝肝纤维化的阻断作用。 6 5例慢性乙肝患者随机分为对照组和IFN组 ,动态观察治疗前后血清HA、PCⅢ、Ⅳ -C水平及IFN疗效与治疗前肝组织纤维化程度关系。IFN -α治疗后血清HA、PCⅢ、Ⅳ -C水平较治疗前及对照组明显降低（P <0 0 5 ,P <0 0 1） ;IFN无应答组患者治疗前血清HA、PCⅢ水平明显高于应答组（P <0 0 5 ）。IFN -α疗效与治疗前肝组织纤维化分期呈负相关（r=- 0 6 773,P <0 0 5 ）。IFNα对慢性乙肝有明显的抗肝纤维化作用 ,其抗病毒疗效受治疗前肝纤维化程度的影响
- IFN-α /
- 慢性乙型肝炎 /
- 肝纤维化
Abstract: To evaluate the inhibitory effect of IFN-α therapy for hepatic fibrosis in patients with chronic hepatitis B. Sixty five patients with chronic hepatitis B were divided into IFN group and control group. The dynamic alteration of serum HA, PCⅢ, Ⅳ-C and histological changes were observed respectively. After treatment with IFN-α the serum HA, PCⅢ, Ⅳ-C levels were significantly decreased in IFN group. Serum HA, PCⅢ levels in non-responders were significantly higher than those in responders before treatment with IFN-α. The effect of IFN was negative correlated to fibrosis stage of hepatic tissue. These fibrosis in patients with chronic hepatitis B and high serum HA, PCⅢ levels before treatment may be related to a poor response to IFN.
- IFN-α /
- chronic hepatitis B /
- hepatic fibrosis

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参考文献(6)

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