α-2b干扰素、病毒唑、胸腺肽治疗30例慢性丙型肝炎疗效观察

邵春忠; 陈晓霞; 袁西侠; 苏菁; 郑军梅; 李瑛

α-2b干扰素、病毒唑、胸腺肽治疗30例慢性丙型肝炎疗效观察

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中图分类号: R512.63
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出版历程
- 出版日期: 2002-03-20

Observation on the effect of α-2b interferon and ribavirin and thymus peptide joint treatment for the 30 patients with chronic hepatitis C.

摘要

摘要: 应用α - 2b干扰素、病毒唑、胸腺肽三联治疗慢性丙型肝炎 30例 ,并与α - 2b干扰素、病毒唑二联治疗 30例慢性丙型肝炎疗效做对比观察。结果显示三联治疗组患者ALT持续复常率显著高于二联组（P <0 .0 1） ,三联组HCVRNA持续转阴率显著高于二联组（P <0 0 5 ） ,三联组治疗期间 ,血色素下降、厌食、体重减轻等副反应发生率显著低于二联组 ;三联治疗能提高对慢性丙型肝炎的治疗效果。
- α-2b干扰素 /
- 病毒唑 /
- 胸腺肽 /
- 慢性丙型肝炎
Abstract: Applied the α-2b interferon and ribavirin and thymus peptide in triad treatment for 30 patients with chronic Hepatitis C, and made a matched observation with the α-2b interferon and ribavirin in bi-treatment for them.The result manifest:the ALT normal-recovery rate was notably the group with triad treatment higher than that of the group with bi-treatment (P<0.01) , the HCVRNA met-negative rate the group with triad treatment was notably higher than that of the bi-treatment group.During the period with triad treatment, the side effects (the descent of hemochrome, anorexia, body weight loss, etc) were lower than those of the bi-treatment group.The triad treatment can improve the treatment effect for the chronic hepatitis C.
- b interferon /
- ribavirin /
- thymus peptide /
- chronic hepatitis C

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参考文献(3)

[1] 基因工程干扰素α-1b干扰素治疗丙型肝炎临床研究协作组基因工程干扰素α-1b治疗慢性丙型肝炎[J].实用肝病杂志, 1997, 2 (1) ∶14—17

[2]Reichard0, NorkranSG , FrydenA , etal.Randomised, double-blind, placebocontrolledtrialofinterferon-α-2bwithandwithoutribavirinforhepatitisC[J].Lancet, 1998, 351 (9096) ∶83-7.

[3]段中平, 程瑞, 王宝恩抗病毒后胸腺肽再治疗对丙型肝炎患者持续反应的影响[J].实用肝脏病杂志, 19972 (41) ∶1995-1996.

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