拉米夫定联合苷必妥治疗慢性乙型肝炎病人的近期疗效

王军; 李勇富; 胡巧玲; 张流

拉米夫定联合苷必妥治疗慢性乙型肝炎病人的近期疗效

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中图分类号: R512.62
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出版历程
- 出版日期: 2001-03-20

Short-term effect of Lamivudine with Gan Bi Tuo treatment in patients with hepatits B

摘要

摘要: 研究拉米夫定联合苷必妥治疗慢性乙型肝炎病人的近期疗效和安全性。选择 16例慢性乙型肝炎患者用拉米夫定 (10 0mg/d)和苷必妥 (1mg/d)治疗为观察组 ,选择 15例患者单独服用拉米夫定 (10 0mg/d)作对照 ,共治疗 12周。疗效评估包括肝功能和HBV复制指标。治疗 12周疗程结束时 ,血清HBVDNA阴转率在两组间差异无显著性 (10 0 %对 80 0 % ,P >0 0 5 ) ,观察组HBeAg阴转率显著高于对照组 (87 5 %对 2 6 7% ,P <0 0 1) ,HBeAg血清转换率在两组间差异有显著性 (78 6 %对 2 5 0 % ,P <0 0 5 ) ,观察组ALT的复常率显著高于对照组 (10 0 0 %对6 6 7% ,P <0 0 5 )。未发生不良反应。拉米夫定联合苷必妥治疗慢性乙型肝炎的近期疗效肯定 ,安全性好
- 乙型肝炎 /
- 乙型肝炎病毒 /
- 拉米夫定 /
- 苷必妥
Abstract: To evaluate the short-term effect and safety of Lamivudine with GanBiTuo (Transfer Factor against Hepatitis B) treatment in chronic hepatitis B patients.31 patients with chronic hepatitis B enrolled were randomized into observed goup (16 cares) , which were administered Lamivudine 100mg and GanBiTuo.1mg daily for 12 weeks, and control group (15cares) , which were adnimisteral Lamivudine 100mg daily for 12 weeks.The liver function and HBV markers were examined.There were no significant difference between the HBVDNA response rate of two groups (100% VS 80.0%, P>0.05) .HBeAg response rate in obrerved group was higher than in control group (87.5% VS 26.7%, P<0.01) .Proportion of HBeAg/anti-HBe seroconversion had difference between two groups (78.6% VS 25.0%, P<0.05) .ALT normalization rate in observed grop was higher than in control group (100% vs 66.7%, P<0.05) .There was few drug-related adverse event.HBV replication could be inhibited by short-term treatment with Lamivudine/GanBiTuo accompanied with good efficacy and safety.
- Hepatitis B /
- Hepatitis B virus /
- Lamivadine /
- Gan Bi Tuo

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参考文献(6)

[1]姚光弼 , 王宝恩 , 等 .拉米夫定治疗慢性乙型肝炎病人的长期疗效[J] 中华肝脏病杂志 , 1999, 7∶80 .

[][2 ]拉米夫定临床应用专家指导小组 .拉米夫定临床应用指导意见 (初稿 ) [J] 中华肝脏病杂志 , 1999, 7∶189.

[3]LaiCL , ChingCK , TungAKM , etal.LamivudineiseffectiveinsuppressingheaptitsBvirusBvirusDNAinChinesehepatitisBsur faceantigencarriers :A placebocon -trolledtrial[J] Hepatology , 1997, 2 5∶2 41.

[4]LaiCL , chienRN , LeungNWY , etal.One -yeartrialofLamivu dineforchronichepatitisB[J] NEngJMed , 1998, 339∶6 1.

[][5 ]王耀宗 .拉米夫定治疗慢性HBV感染 [J] 国外医学流行病、传染病学分册 , 1999, 2 6∶114 .

[][6 ]白珠德 , 杨军苷必妥治疗慢性乙型肝炎疗效观察 [J] 上海医药 , 1998, 19 (5 ) ∶10

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