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Analysis on the relationship between IFN-γ and HA、PⅢP、Ⅳ-c、LN serum level for hepatocirrhosis
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摘要: 检测 5 8例肝炎肝硬化患者血清γ 干扰素 （IFN -γ）和肝纤维化标志物HA、PⅢP、Ⅳ -c、LN的结果。有 35例 （6 0 34 % ）血清IFN -γ水平降低 ,11例 （18 97% ）升高。血清IFN -γ降低者肝纤维化标志物升高明显。肝功能异常的活动性肝硬化患者血清IFN -γ水平较静止期肝硬化患者为高 （P <0 0 5 ）。提示 ,测定肝炎肝硬化患者外周血IFN -γ的含量 ,结合血清肝纤维化标志物的水平 ,可能对使用IFN -γ抗纤维化治疗提供有一定价值的依据。Abstract: WT5”BZ]the serum level of γ Interferon (IFN-γ) , type Ⅳ collagen (Ⅳ-c) , hyaluyonidase (HA) , laminin (LN) , propeptide Ⅲ procollagen (PⅢP) in 58 patients with hepatocirrohosis were tested Results show that serum concentration of IFN-γ gradually decrease in the 35 cases (60 34%) , only 11 case increase (18 975) At the same time, patients with lower serum IFN-γ concentrations were significantly higher in hepatic fibrosis markers (P<0 05) The serum level of IFN-γ in the hepatocirrhosis patients of liver function abnormal were lower than the patients of steady hepatocirrhosis (P<0 05) It is valuable that The test IFN-γ and the hepatic fibrosis markers at the same time for the treatment of hepatic fibrosis [WT5”HZ]
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Key words:
- WT5”BZ]IFN-γ /
- Hepatic fibrosis markers /
- hepatocirrhosis
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[1]叶维法 , 钟振义主编 临床肝胆病学 [M ] 天津 :天津科技出版社 , 1997∶P5 72 [2 ]张罗修 , 主编 免疫药理学 [M ] 上海 :上海医科大学出版社 , 1983∶P12 4 [][3 ]高寿征 , 主编 病毒性肝炎防治研究 [M ] 北京 :北京出版社 , 1994∶P92 [4] 刘树生 乙型肝炎抹末梢血淋巴细胞产生白细胞介素 2及免疫干扰素功能的异常 [J] 中华医学杂志 , 1986, 66 (7) ∶413 [][5 ]蔡卫民 , 陈智 , 陈峰 , 等 γ 干扰素抗肝纤维化临床疗效初步观察[J] 临床肝胆病杂志 , 1998, 14 (1) ∶2 3 -
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