慢性乙型病毒性肝炎患者血清可溶性细胞间粘附分子-1作用的初步探讨

尹洪竹; 刘金星; 曹治宸; 李兵顺; 汤慧华; 冯忠军

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慢性乙型病毒性肝炎患者血清可溶性细胞间粘附分子-1作用的初步探讨

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出版历程
- 出版日期: 2000-04-20

The Study of the role of Soluble Intercellular Adhesion Molecule-1 in Patients with Chronic hepatitis B

摘要

摘要: 探讨可溶性细胞间粘附分子 - 1（sICAM 1）在慢性乙型肝炎中的作用及临床意义。应用酶联免疫吸附试验检测 5 6例慢性乙型肝炎患者血清sICAM 1水平。慢性乙型肝炎患者血清sICAM 1水平明显高于正常人水平 ,且随着肝细胞损伤程度的加重而升高 ,与T细胞亚群无相关性。血清sICAM - 1水平可反映慢性乙型肝炎患者的病情及肝细胞坏死程度 ,不能直接影响其细胞免疫功能。
- 可溶性细胞间粘附分子-1 /
- 慢性乙型肝炎 /
- 细胞免疫
Abstract: To evealuate the biologic role of soluble intercellular adhesion molecule 1 (sICAM 1) in chronic hepatitis B (CHB) .serum sICAM 1 was detected by ELISA in 56 patients with CHB.Serum sICAM 1 level in CHB was notably higher than in NC (P<0.01/0.05) and paralleled with the serious degree of liver damage, there were no correlations with CD + 4+, CD + 8 or the ratio of CD + 4/CD + 8.Serum sICAM 1 level increase in CHB and consist with liver damage, it can not influence cellular immune function.
- Soluble intercellular adhesion molecule 1 /
- cellular immune /
- Chronic hepatitis B

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参考文献(4)

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[]〔2〕RothleinR , MainolfiEA , CzajkowskiM , etal.AformofcirculatingI CAM 1inhumanserum〔J〕 .JImmunol, 1991, 14 7∶3788.

[]〔3〕SatohS , NusslerAK , LiuZZ , etal.Proinflammatorycytokinesandendo toxinstimulateICAM 1geneexpressionandsecretionbynormalhumanhepa tocytes〔J〕 .Immunol, 1994, 82∶5 71.

[]〔4〕BeckerJC , TermeerC , SchmidtRE , etal.Solubleintercellularadhesionmolecule 1inhibitsMHC restrictedspecificTcell/tumorinteraction〔J〕 .JImmunol, 1993, 15 1∶72 2 4.

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