乙肝病毒血清学指标与肝组织病毒存在状况的关系

赵建平; 赵丽莉; 陈煜

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乙肝病毒血清学指标与肝组织病毒存在状况的关系

洛阳市第二人民医院!河南洛阳471009
山东医科大学!山东济南250012

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出版历程
- 出版日期: 2000-04-20

The relation between the serum index of hepatitis B virus and its existence in hepatic tissue

摘要

摘要: 研究乙肝病毒血清学指标与肝组织病毒存在状况的关系。用聚合酶联反应和免疫组织化学方法分别检测了不同就诊者肝组织HBVDNA和乙肝病毒核心抗原的存在状况 ,同时分析了肝组织病理学变化。在部分血清HBsAg阴性而仅检测出病毒抗体的就诊者肝组织内检出了乙肝病毒DNA和核心抗原。其中一部分就诊者肝组织病理学表现为慢活肝和早期肝硬化。不少患者仅检测出血清中乙肝病毒抗体 ,但体内仍有乙肝病毒的存在 ,肝组织有不同程度的慢性炎症。
- 乙肝病毒DNA /
- 乙肝病毒核心抗原 /
- 聚合酶联反应 /
- 免疫组织化学
Abstract: To research the relation between the serum index of hepatitis B rirus and its existence in hepatic tissue Polymerase chain reaction and immunomistochemistry stammg technique were nsed to detect the existence of HBVDNA and HBcAg respectively in the hepatic tissues of different out-patitents Both HBVDNA and HBcAg were detected in some patients whose serums were HBsAg negative while anti-HBV antilodies were positive chemhes in some of them are chronic active hepatitis or early liver cirrhosis The hepatic tissues of some patients whose serums were HBsAg-negative were infected by hepatitis B virus and had different chronic inflammation
- HBVDNA /
- HBcAg /
- Polymerase chain reaction /
- immunohistochemistry

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参考文献(2)

[]〔1〕KoikeK , OmataM , BaginskiI, etal, StateofBvirusKNAinhepatocytesofpatientswithhepatitisBsukfaceantigenpositiveliverdisease〔J〕 MolBioMed , 1989, 6 (2 ) ∶15 1

[]〔2〕Junkokato, kiyoshiHasegawa, NobuyukiTorii, etal AmoleowaranalysisofviralpersistenceinsurfaceantigennegativechronichepatitisB〔J〕 Hepatology , 1996 , 2 3 (3) ∶389

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