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Study of Intestinal Metaplasia in Chronic Cholecytitis
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摘要: 探讨慢性胆囊炎肠上皮化生的发生率、类型及其与胆囊结石和不典型增生的关系。对 1339例慢性胆囊炎组织中肠上皮化生和不典型增生的发生率分别为 39 96 %和 0 97% ;慢性胆囊炎的肠上皮化生至少可以分为结肠型、小肠型和混合型三种 ;肠上皮化生尤其是结肠型与不典型增生有密切的关系 ;肠上皮化生和不典型增生与有无合并胆囊结石无关。慢性胆囊炎的肠上皮化生尤其是结肠型肠上皮化生可能与胆囊癌的发生有密切关系Abstract: WT5”BZ]To study the rate and type of intestinal metaplasia, and the relationship between intestinal metaplasia and atypical hyperplasia in lithiasis and chronic cholecystitis 1339 cases were studied for intestinal metaplasia and atypical hyperplasis through routine staining (HE) and 78 cases were studied for intestinal metaplasia through histochemical staining (AB, pH=1 0) Rates of intestinal metaplasia and atypical hyperplasm were 39 96% and 0 97% in 1339 cases of chronic cholecystitis:the intestinal metaplasia in chronic cholecystitis may be classified as three types:colonic type, small intestinal type and combined type;intestinal metaplasia, especially the colonic type, was related with atypical hyperplasm;no relationship was found between intestinal metaplasia, atypical hyperplasia and lithiasis Instestinal metaplasia in chronic cholecystitis, especially the colonic type, may be related closely with carcinogenesis in the gallbladder [WT5”HZ]
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〔1〕巫协宁 :胆囊 , 胆管和壶腹周围肿瘤。见 :江绍基主编 , 临床肝胆系病学 , 上海 :上海科学技术出版社 , 1992∶60 0 []〔2〕Brand -RPW Cancerofthegallbladder:Areviewofforty -fourcas es HumanPathology , 1982 , 13∶48 []〔3〕朱世能 :肝胆肿瘤。见 :刘复生 , 刘彤华主编 , 肿瘤病理学。北京 :北京医科大学中国协和医科大学联合出版社 , 1997, 93 6 []〔4〕蚁国铮 , 李晓明 , 卢俊。胆囊免疫组织化学与病理形态的研究。临床与实验病理学杂志 , 1989, 5 ( 3 ) ∶167 〔5〕周正端 :胆囊肿瘤。见 :曹绣虎 , 周正端 , 陈国忠主编。胆道肿瘤诊断和治疗。第一版。广州 :广东科技出版社 , 1994, 65 []〔6〕KinoshitaH , NagataE , HirohashiK , etal Carcinomaofthegallbladderwithananomalousconectionbetweenthecholedochusandpancreaticduct Cancer, 1984, 5 4∶762 〔7〕刘介眉 , 赵希顺 , 虞积耀。鉴别胃粘膜大肠型化生的几种组织化学染色方法。中华病理学杂志 , 1983 , 12 ( 2 ) ∶15 2 〔8〕张荫昌 :胃及贲门癌。见 :刘复生 , 刘彤华主编 , 肿瘤病理学。北京 :北京医科大学中国协和医科大学联合出版社 , 1997, 62 4 []〔9〕JassJR Roleofintestinalmetaplasiainthehistogenesisofgastriccarcino ma JClinPathol, 1980 , 3 3∶80 1 〔10〕阎瑞方 , 张荫昌 , 张佩范 , 等。用组织化学和免疫组织化学方法观察胃粘膜肠上皮化生与胃癌的关系。中华病理学杂志 , 1983 , 12 ( 2 ) ∶175 -
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