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A Study on the relationship between HCV infection and p53 and p21WAF1/CIP1 aberrant expression in primary cholangiocellular carcinoma
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摘要: 为探讨丙型肝炎病毒 （HCV）感染与p5 3和 p2 1WAF— /CIP1基因的关系。采用免疫组化技术对 2 9例原发性肝胆管癌中HCV抗原 （NS5-Ag）、p5 3和 p2 1WAF1/CIP1蛋白表达进行研究。结果 :2 9例胆管癌中NS5-Ag、p5 3及p2 1WAF1/CIP1蛋白表达进行研究。结果 :2 9例胆管癌中NS5-Ag、p5 3及 p2 1WAF1/CIP1的阳性率分别为 5 1.7% （15 /2 9） ,48.3% （14/ 2 9）和 72 .4% （2 1/ 2 9）。NS5-Ag阳性与阴性组间 p5 3和 p2 1WAF1/CIP1的表达有明显差异 （p <0 .0 5 ）。结论 :p5 3和 p2 1WAF1/CIP1基因可能参与胆管上皮的癌变过程 ,p5 3和 p2 1WAF1/CIP1表达异常与HCV感染有一定关系。
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关键词:
- 胆管癌 /
- HCV /
- p53 /
- p21WAF1/CIP1
Abstract: Aim to study the relationship between HCV infection and p53 and p21 WAF1/CIP1 gene and hepatic cholangiocarcinoma genesis.HCV NS 5 antigen, p53 and p21 WAF1/CIP1 gene expression in 29 cases of primary hepatic cholangiocarcinoma (PHC) were detected using immunohistochemistry technique.Results:15 cases (51.7%) were positive for HCV NS5 antigen and 14 cases (48.3%) for p53 and 21 cases (72.45) for p21 WAF1/CIP1 in 29 cases of PHC respectively.In 15 HCV NS5 positive cases 11 cases and 15 cases were positive for p53 and p21 WAF1/CIP1 respectively;In 14 HCV NS5 negaive cases, 3 cases and 6 cases were positive for p53 and p21 WAF1/CIP1 respectively.There were statistically differences between them (P<0.05) .Conclusion:p53 and p21 WAF1/CIP1 may involved in carcinomagenesis of bile duct epithelium.HCV infection may have a clear effect on p53 and 21 WAF1/CIP1 protein expression.-
Key words:
- Cholangiocarcinoma /
- HCV p53 gene p21 WAF1/CIP1 gene /
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[1]王春杰 , 王文亮和王伯云 , 肝内胆管细胞癌中 HCVRNA及其NS3区抗原的分布及意义 , 中国病毒学 , 1996, 11 ( 1) ∶2 9 [][2 ]王春杰 , 王文亮和王伯云 , 丙型肝炎病毒C3c抗原、核心抗原和HBxAg人原发性肝内胆管癌中的分布及意义 , 第四军医大学学报 , 1996, 17 ( 4 ) ∶2 41 [][3 ]NasmythK , HunterT .Cellcycle:Damsandsluices .Nature, 1993 , 3 66∶63 4 [4]HunterT .Brakingthecycle .Cell, 1993 , 75∶83 9 [][5 ]HortwellLH , KastanMB .Cellcyclecontrolandcancer.Science , 1994, 2 66∶182 1 [6]RayRB , SteeleR , MeyerK , etal.Transcriptionalrepressionofp5 3promoterbyhepatitisCvirusvorpotein .JBiolChem , 1997, 2 72 :10 983 -
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