肿瘤相关成纤维细胞与肝癌的关系

胡晓; 毛德文; 牙程玉

doi:10.3969/j.issn.1001-5256.2021.02.041

肿瘤相关成纤维细胞与肝癌的关系

DOI: 10.3969/j.issn.1001-5256.2021.02.041

1.
广西中医药大学研究生学院，南宁 530001
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金面上项目 (81774236);

国家自然科学基金 (81460718);

国家“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项 (2018ZX10725504-001-008);

广西研究生教育创新计划资助项目 (YCSY2020090)

作者贡献声明：胡晓负责拟定写作思路，撰写文章并最后定稿；毛德文教授负责对文章的知识性内容做批判性审阅；牙程玉参与文章修订。

详细信息

作者简介:
胡晓(1994—)，女，主要从事中医药防治肝病的研究

通信作者:
毛德文，mdwboshi2005@163.com

中图分类号: R735.7
计量
- 文章访问数: 309
- HTML全文浏览量: 413
- PDF下载量: 42
- 被引次数: 0
出版历程
- 收稿日期: 2020-08-07
- 录用日期: 2020-09-11
- 出版日期: 2021-02-20

Association between cancer-associated fibroblasts and liver cancer

Xiao HU¹,
Dewen MAO^{2
, ,},
Chengyu YA¹

1.
Graduate School, Guangxi University of Chinese Medicine, Nanning 530001, China
2.
First Ward of Liver Diseases, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

摘要

摘要: 我国肝病多发，肝癌一直是国民健康的一大威胁，目前临床针对肝癌的防治手段效果欠佳，随着研究的不断深入，学者们将焦点转向了肿瘤微环境中的肿瘤相关成纤维细胞，越来越多的证据表明肿瘤相关成纤维细胞或可为肝癌防治提供全新靶位。现就肿瘤相关成纤维细胞在肝癌发生发展中的作用及在肝癌治疗中的潜力作一综述。
- 肝肿瘤 /
- 癌相关成纤维细胞 /
- 肿瘤微环境
Abstract: Liver cancer has always been a threat to national health since liver disease has a high incidence rate in China. At present, methods for the prevention and treatment of liver cancer have unsatisfactory effects in clinical practice, and with in-depth studies, scholars have changed their focus to cancer-associated fibroblasts (CAFs) in tumor microenvironment. More and more evidence has shown that CAFs may provide a new target for the prevention and treatment of liver cancer. This article summarizes the role of CAFs in the development and progression of liver cancer and the potential of CAFs in the treatment of liver cancer.
- Liver Neoplasms /
- Cancer-Associated Fibroblasts /
- Tumor Microenvironment

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参考文献(35)

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