无干扰素抗HCV方案的研究进展

李强; 黄玉仙; 陈良

doi:10.3969/j.issn.1001-5256.2016.01.037

无干扰素抗HCV方案的研究进展

DOI: 10.3969/j.issn.1001-5256.2016.01.037

复旦大学附属公共卫生临床中心肝炎一科

基金项目:

上海市科委“科技创新行动计划”医学与农业领域重点项目(13401902100)；上海市卫生局临床医学应用研究项目(20114279)；

详细信息

中图分类号: R512.63
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- 被引次数: 0
出版历程
- 收稿日期: 2015-04-28
- 出版日期: 2016-01-20

Research progress in anti-HCV therapeutic regimens without interferon

First Department of Hepatitis,Public Health Clinical Center Affiliated to Fudan University

Research funding:

摘要

摘要: 当前,全球约有1.5亿慢性HCV感染者,其中20%会进展为肝硬化并最终死于终末期肝病和肝癌。干扰素(IFN)长期作为慢性丙型肝炎治疗的基石,在维持持续病毒学应答以及阻止病情进展方面有重要作用,但其疗效有限、不良反应多。近年来,直接抗病毒药物(DAAs)呈现出良好的疗效,在DAAs的基础上,介绍了无IFN抗HCV方案的最新研究进展,认为随着DAAs的出现,无IFN抗HCV方案发展迅速,前景较好。
- 肝炎,丙型,慢性 /
- 抗病毒药 /
- 蛋白酶抑制药 /
- 综述
Abstract: There are about 150 million people around the world with chronic hepatitis C virus( HCV) infection currently,of whom 20%will ultimately progress to cirrhosis and eventually die of end- stage liver disease and hepatocellular carcinoma. Interferon( IFN) has long been recognized as the cornerstone of the treatment of chronic hepatitis C because of its role in sustained virologic response and prevention of disease progression. However,it has limited efficacy and multiple adverse effects. In recent years,direct- acting antiviral agents( DAAs)have shown good efficacy. This review summarizes the recent advances in IFN- free anti- HCV therapeutic regimens based on DAAs. We believe that,with the emergence of DAAs,IFN- free therapies will develop rapidly and display better prospects.
- hepatitis C,chronic /
- antiviral agents /
- protease inhibitors /
- review

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参考文献(31)

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