低剂量阿德福韦酯致范可尼综合征合并低磷性骨软化症1例报告

王守庆; 赵娜; 辛桂杰

doi:10.3969/j.issn.1001-5256.2016.01.033

低剂量阿德福韦酯致范可尼综合征合并低磷性骨软化症1例报告

DOI: 10.3969/j.issn.1001-5256.2016.01.033

吉林大学第一医院肝病科

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中图分类号: R595.3
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出版历程
- 出版日期: 2016-01-20

Fanconi syndrome with hypophosphatemic osteomalacia induced by low-dose adefovir dipivoxil

Department of Hepatology,The First Hospital of Jilin University

摘要

摘要: <正>阿德福韦酯(ADV)是一种口服单磷酸腺苷核苷酸类药物[1],2002年9月在美国被批准用于治疗慢性乙型肝炎(CHB),2005年4月在中国上市。既往认为小剂量ADV无明显肾毒性[2];近年来,有关长期低剂量使用ADV(10 mg/d)导致肾损伤的报道不断增加。本院收治因服用ADV(10 mg/d)80个月,导致范可尼综合征合并低磷性骨软化症患者1例,现
- 阿德福韦酯 /
- 范科尼综合征 /
- 骨软化症 /
- 病例报告
- adefovir dipivoxil /
- fanconi syndrome /
- osteomalacia /
- case reports

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参考文献(10)

[1]WANG JB,KANG HY,CAO XG,et al.The effect of LAM or ADV add-on therapy for HBeA g negative chronic hepatitis B patients with suboptimal response to PEG-IFN[J].Int J Virol,2015,22(5):310-314.(in Chinese)王建彬,康海燕,曹雪改,等.聚乙二醇干扰素应答不佳HBeA g阴性慢性乙肝患者加用拉米夫定或阿德福韦酯疗效观察[J].国际病毒学杂志,2015,22(5):310-314.

[2]IZZEDINE H,HULOT JS,LAUNAY-VACHER V,et al.Renal safety of adefovir dipivoxil in patients with chronic hepatitis B:two double-blind,randomized,placebo-controlled studies[J].Kidney Int,2004,66(3):1153-1158.

[3]MAO YM,ZENG MD.Adefovir dipivoxil——a new drug for hepatitis B[J].Chin J Hepatol,2004,12(1):61-63.(in Chinese)茅益民,曾民德.抗乙型病毒性肝炎新药——阿德福韦酯[J].中华肝胆病杂志,2004,12(1):61-63.

[4]GARA N,ZHAO X,COLLINS MT,et al.Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B[J].Aliment Pharmacol Ther,2012,35(11):1317-1325.

[5]WANG BF,WANG Y,WANG BY,et al.Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil[J].J Clin Pharm Ther,2015,40(3):345-348.

[6]SHIMIZU M,FURUSYO N,IKEZAKI H,et al.Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B[J].World J Gastroenterol,2015,21(7):2116-2123.

[7]WANG XB,ZHU XC,HUANG XY,et al.Fanconi syndrome due to prolonged use of low-dose adefovir[J].J Res Med Sci,2015,20(4):416-419.

[8]JEONG HJ,LEE JM,LEE TH,et al.Two cases of hypophosphatemic osteomalacia after long-term low dose adefovir therapy in chronic hepatitis b and literature review[J].J Bone Metab,2014,21(1):76-83.

[9]TANAKA M,SETOGUCHI T,ISHIDOU Y,et al.Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B:a case report[J].Diagn Pathol,2012,7:108.

[10]JIA HY,DING F,CHEN JY,et al.Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B[J].World J Gastroenterol,2015,21(12):3657-3662.

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