复发性胆源性胰腺炎的临床特点及诱发因素分析

吕坤; 陈翔

doi:10.3969/j.issn.1001-5256.2016.01.024

复发性胆源性胰腺炎的临床特点及诱发因素分析

DOI: 10.3969/j.issn.1001-5256.2016.01.024

吕坤,
陈翔

1. 重庆市红十字会医院江北区人民医院普外科
2. 重庆市第四人民医院肝胆外科

详细信息

中图分类号: R576
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出版历程
- 收稿日期: 2015-05-14
- 出版日期: 2016-01-20

Clinical features of recurrent biliary pancreatitis and its predisposing factors

Lu: Kun,
Chen Xiang

Department of General Surgery,Chongqing Red Cross Hospital ( Jiangbei District People' s Hospital)

摘要

摘要: 目的探讨复发性胆源性胰腺炎的临床特点及诱发因素。方法选取江北区人民医院2008年1月-2014年12月收治的272例胆源性胰腺炎患者,其中复发性胆源性胰腺炎56例（复发组）,初发性胆源性胰腺炎216例（初发组）。比较2组患者的临床特点和诱因。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果 2组患者的年龄、病死率比较,差异均无统计学意义（P值均>0.05）。与初发组比较,复发组中男性所占比例、APACHE-Ⅱ评分、中重度胰腺炎、胆总管结石发生率、合并胆总管开口狭窄率、合并高脂血症率、手术治疗率均显著升高（P值均<0.05）。复发组复发2次者与复发2次以上者的胰腺炎分型比较,差异亦有统计学意义（P=0.040）。复发组有明确诱因者明显高于初发组（80.36%vs 58.33%,P=0.002）。复发组中高脂饮食、饮酒率明显高于初发组（P值均<0.05）,但是2组胆道感染、口服药物率的差异无统计学意义（P值均>0.05）。结论复发性胰腺炎在男性中多见,相对较重,常合并胆总管结石、胆总管开口狭窄、高脂血症,手术治疗率高。高脂饮食和饮酒是复发性胆源性胰腺炎...
- 胰腺炎 /
- 复发 /
- 危险因素
Abstract: Objective To investigate the clinical features of recurrent biliary pancreatitis and related predisposing factors. Methods A total of 272 patients with biliary pancreatitis who were admitted and treated in Jiangbei District People's Hospital from January 2008 to December 2014 were enrolled and divided into recurrence group( 56 patients with recurrent biliary pancreatitis) and primary group( 216 patients with primary biliary pancreatitis). Clinical features and predisposing factors were compared between the two groups. Comparison of continuous data between the two groups was made by t test and comparison of categorical date was made by chi- square test. Results There were no significant differences in age and mortality between the two groups( both P > 0. 05). Compared with the primary group,the recurrence group had a significantly higher proportion of males,a significantly increased APACHE- Ⅱ score,significantly increased incidence rates of moderate- to- severe pancreatitis and common bile duct stones,significantly higher rates of stenosis of the common bile duct orifice and hyperlipidemia,and a significantly higher rate of surgical treatment( all P < 0. 05). In the recurrence group,the type of pancreatitis differed significantly between patients with 2 times of recurrence and those with > 2 times of recurrence( recurrence for more than 2 times)( P =0. 040). Compared with the primary group,the recurrence group had a significantly higher proportion of patients with known predisposing factors( 80. 36% vs 58. 33%,P = 0. 002),as well as significantly higher rates of high- fat diet and drinking( both P < 0. 05). However,the rates of biliary tract infection and oral administration of drugs showed no significant differences between the two groups( both P > 0. 05).Conclusion Recurrent biliary pancreatitis is common and severe in males,and is often complicated by common bile duct stones,stenosis of the common bile duct orifice,and hyperlipidemia,with a high rate of surgical treatment. High- fat diet and drinking are important predisposing factors for recurrent biliary pancreatitis.
- pancreatitis /
- recurrence /
- risk factors

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参考文献(12)

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