经内镜逆行胰胆管造影术后高淀粉酶血症的危险因素分析

依尔潘·艾山; 高峰

doi:10.3969/j.issn.1001-5256.2016.01.022

经内镜逆行胰胆管造影术后高淀粉酶血症的危险因素分析

DOI: 10.3969/j.issn.1001-5256.2016.01.022

新疆维吾尔自治区人民医院消化科

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中图分类号: R576
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出版历程
- 收稿日期: 2015-05-11
- 出版日期: 2016-01-20

Risk factors for hyperamylasemia after endoscopic retrograde cholangiopancreatography

Department of Gastroenterology,The People' s Hospital of Xinjiang Uygur Autonomous Region

摘要

摘要: 目的探讨经内镜逆行胰胆管造影（ERCP）术后高淀粉酶血症（PEPH）发生的危险因素。方法对2012年1月-2014年12月在新疆维吾尔自治区人民医院行治疗性ERCP并符合纳入标准的233例患者的临床资料进行回顾性分析,提取患者年龄、性别、饮酒史、单发结石、甘油三酯、民族等基本信息并详细录入ERCP术中操作、术中诊断以及并发症等情况。计数资料组间比较采用χ2检验,采用Logistic回归分析寻找PEPH发生的危险因素。结果 PEPH发生率为26.6%（62/233）。单因素分析显示女性（χ2=3.320,P=0.045）、有饮酒史（χ2=6.108,P=0.010）、胆总管狭窄（χ2=5.767,P=0.012）、单发结石（χ2=9.121,P=0.020）、十二指肠乳头憩室（χ2=28.170,P<0.001）、异常的甘油三酯（χ2=54.717,P<0.001）为PEPH发生的影响因素。多因素Logistic回归分析显示女性[比值比（OR）=1.616,P=0.025]、饮酒史（OR=2.360,P=0.010）、胆总管狭窄（OR=2.163,P=0.012）、十二指肠乳...
- 高淀粉酶血症 /
- 胰腺炎 /
- 胰胆管造影术,内窥镜逆行 /
- 危险因素
Abstract: Objective To investigate the risk factors for the development of post- endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasemia( PEPH) after endoscopic retrograde cholangiopancreatography( ERCP). Methods The clinical data of 233 patients who underwent therapeutic ERCP from January 2012 to December 2014 in our hospital and met the inclusion criteria were analyzed retrospectively. Basic information including age,sex,drinking history,single stone,triglyceride,and nationality was extracted,and detailed information on intraoperative procedure,intraoperative diagnosis,and complications for ERCP was carefully recorded. Chi- square test was applied for comparison of categorical data between groups,and Logistic regression analysis were applied to determine the risk factors for the development of PEPH. Results The incidence of PEPH was 26. 6%( 62 /233). Univariate analysis showed that female sex( χ2= 3. 320,P= 0. 045),drinking history( χ2= 6. 108,P = 0. 010),common bile duct stenosis( χ2= 5. 767,P = 0. 012),single stone( χ2= 9. 121,P= 0. 020),juxta- ampullary duodenal diverticula( χ2= 28. 170,P < 0. 001),and abnormal triglyceride( χ2= 54. 717,P < 0. 001) might be the risk factors for PEPH,and these factors differed significantly between the two groups. Multivariate analysis showed that female sex( OR = 1. 616,P = 0. 025) drinking history( OR = 2. 360,P = 0. 010),common bile duct stenosis( OR = 2. 163,P = 0. 012),juxta- ampullary duodenal diverticula( OR = 5. 502,P < 0. 001),and abnormal triglyceride( OR = 12. 924,P < 0. 001) were independent risk factors for PEPH. Conclusion Female sex,drinking history,common bile duct stenosis,juxta- ampullary duodenal diverticula,and abnormal triglyceride are independent risk factors for PEPH,and targeted preventive measures for such high- risk populations can effectively reduce the incidence of PEPH.
- hyperamylasemia /
- pancreatitis /
- cholangiopancreatgraphy,endoscopic retrograde /
- risk factors

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