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IgG4 相关性肝胆胰疾病的发病机制
Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases
文章发布日期:2019年05月13日  来源:  作者:张德华,赵婕  点击次数:729次  下载次数:146次

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【摘要】:IgG4相关性疾病(IgG4-RD)是一种可累及全身的多系统的慢性进行性自身免疫性疾病,IgG4相关性肝胆胰疾病为IgG4-RD受累肝胆胰腺系统表现,其主要特征为血清IgG4水平升高和IgG4阳性淋巴浆细胞浸润,可模仿各种炎症及肿瘤疾病,临床易漏诊误诊。从基因遗传、感染与分子模拟、免疫因素等方面阐述IgG4相关性肝胆胰疾病的发病机制,从而提高对该病的认识。
【Abstract】:Immunoglobulin G4 (IgG4)-related disease is a chronic progressive autoimmune disease involving multiple systems throughout the body. IgG4-related hepatobiliary and pancreatic diseases are the manifestation of IgG4-related disease involving the hepatobiliary and pancreatic systems, with the main features of an increased serum IgG4 level and IgG4-positive lymphoplasmacytic infiltration. IgG4-related hepatobiliary and pancreatic diseases can mimic various inflammations and tumor diseases, which may lead to missed diagnosis and misdiagnosis in clinical practice. This article elaborates on the pathogenesis of IgG4-related hepatobiliary and pancreatic diseases from the perspectives of genetic inheritance, infection and molecular mimicry, and immune factors, so as to improve the understanding of such diseases.
【关键字】:免疫球蛋白G; 自身免疫疾病; 胰腺炎; 胆管炎, 硬化性; 肝疾病; 综述
【Key words】:immunoglobulin G; autoimmune diseases; pancreatitis; cholangitis, sclerosing; liver diseases; review
【引证本文】:ZHANG DH, ZHAO J. Pathogenesis of immunoglobulin G4-related hepatobiliary and pancreatic diseases[J]. J Clin Hepatol, 2019, 35(6): 1401-1405. (in Chinese)
张德华, 赵婕. IgG4相关性肝胆胰疾病的发病机制[J]. 临床肝胆病杂志, 2019, 35(6): 1401-1405.

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