首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2019年 6期 HBV cccDNA研究进展 => 综述 =>缺血再灌注损伤对肝癌..
缺血再灌注损伤对肝癌的影响及作用机制
Influence of ischemia-reperfusion injury on liver cancer and related mechanism
文章发布日期:2019年05月13日  来源:  作者:郑健豪,戴朝六  点击次数:168次  下载次数:44次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:在肝癌的手术过程中,肝门血流阻断是减少术中出血的主要手段,由此产生的缺血再灌注损伤(IRI)对肿瘤细胞产生了重要的影响。IRI不仅与肿瘤的复发转移有关,也能产生对肿瘤的抑制效应。其影响与自由基、一氧化氮、炎性细胞因子以及酶类等多方面因素相关,不同因素对于肝癌的影响不尽相同。了解其影响以及作用机制,对于研究IRI与肝癌的关系,以及肝癌治疗手段的选择具有重要意义。
【Abstract】:In the process of the surgical treatment of liver cancer, blood flow occlusion at the porta hepatis is an important method to reduce intraoperative bleeding, and ischemia-reperfusion injury (IRI) resulting from such occlusion has an important effect on tumor cell. IRI can not only lead to tumor recurrence and metastasis, but also exert an inhibitory effect on tumor. Such influence is associated with various factors including free radicals, nitric oxide, inflammatory cytokines, and enzymes. An understanding of such effect and related mechanisms is of great importance to the research on the association between IRI and liver cancer and the selection of treatment methods for liver cancer.
【关键字】:再灌注损伤; 肝癌; 自由基; 分子伴侣; 细胞因子类; 综述
【Key words】:reperfusion injury; liver cancer; free radicals; molecular chaperones; cytokines; review
【引证本文】:ZHENG JH, DAI CL. Influence of ischemia-reperfusion injury on liver cancer and related mechanism[J]. J Clin Hepatol, 2019, 35(6): 1369-1373. (in Chinese)
郑健豪, 戴朝六. 缺血再灌注损伤对肝癌的影响及作用机制[J]. 临床肝胆病杂志, 2019, 35(6): 1369-1373.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号