首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2019年 6期 HBV cccDNA研究进展 => 肝脏肿瘤 =>载药微球与传统碘化油..
载药微球与传统碘化油经肝动脉化疗栓塞术治疗不可切除肝癌效果比较的Meta分析
Clinical effect of drug-eluting beads and conventional transcatheter arterial chemoembolization in treatment of unresectable liver cancer: A meta-analysis
文章发布日期:2019年05月13日  来源:  作者:尹伟利,连佳,肖时湘,等  点击次数:287次  下载次数:58次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的系统评价载药微球经肝动脉化疗栓塞术(DEB-TACE)与常规经导管动脉化疗栓塞术(cTACE)经导管动脉化疗栓塞治疗不可切除肝癌的疗效。方法检索PubMed、Embase、Cochrane library和CNKI数据库中有关DEB-TACE与cTACE治疗不可切除肝癌的临床对照试验的文献。根据纳入和排除标准筛选文献,筛选出有效数据后,采用Revman 5.3软件进行Meta分析,比较两者完全缓解(CR)率、部分缓解(PR)率、术后疾病稳定(SD)率、6个月和12个月生存率。结果共纳入12篇文献,共1177例患者,519例患者接受DEB-TACE治疗,658例接受cTACE治疗。与cTACE组相比,DEB-TACE组CR率显著增加[相对风险度(RR)=1.42;95%可信区间(95%CI):1.18~1.72,P=0.0002],术后12个月生存率显著增加(RR=1.09;95%CI:101~117,P=0.03)。两组PR率(RR=1.13;95%CI:0.97~1.30,P=0.12)、SD率(RR=0.82;95%CI:0.64~1.05,P=0.12)、6个月生存率(RR=1.05;95%CI:1.00~1.10,P=0.07)无显著性差异。结论与碘化油TACE相比,载药微球更具疗效优势的趋势。
【Abstract】:ObjectiveTo systematically review the clinical effect of transcatheter arterial chemoembolization with drug-eluting beads (DEB-TACE) versus conventional transcatheter arterial chemoembolization (cTACE) in the treatment of unresectable liver cancer. MethodsPubMed, Embase, Cochrane, and CNKI were searched for articles on clinical control trials of DEB-TACE versus cTACE in the treatment of unresectable liver cancer. The articles were screened according to inclusion and exclusion criteria, and after valid data were extracted, Revman 5.3 software was used for meta-analysis. The two groups were compared in terms of the number of patients with complete remission (CR), partial remission (PR), or stable disease (SD) and 6- and 12-month survival rates. ResultsA total of 12 articles were included, with 1177 patients in total, among whom 519 patients underwent DEB-TACE and 658 underwent cTACE. Compared with the cTACE group, the DEB-TACE group had a significantly higher number of patients with CR (risk ratio [RR]=1.42, 95% confidence interval [CI]: 1.18-1.72, P=0.0002), and had a significantly higher 12-month survival rate (RR=1.09, 95% CI: 1.01-1.17, P=0.03). There were no significant differences between the two groups in the number of patients with PR (RR=1.13, 95% CI: 0.97-130, P=0.12), the number of patients with SD (RR=0.82, 95% CI: 0.64-1.05, P=0.12), 6-month survival rate (RR=1.05, 95% CI: 1.00-1.10, P=0.07). ConclusionDEB-TACE has a better therapeutic effect than cTACE with iodinated oil.
【关键字】:肝肿瘤; 化学栓塞, 治疗性; 微球体; 治疗结果; Meta分析
【Key words】:liver neoplasms; chemoembolization, therapeutic; microspheres; treatment outcome; Meta-analysis
【引证本文】:YIN WL, LIAN J, XIAO SX, et al. Clinical effect of drug-eluting beads and conventional transcatheter arterial chemoembolization in treatment of unresectable liver cancer: A meta-analysis[J]. J Clin Hepatol, 2019, 35(6): 1270-1275. (in Chinese)
尹伟利, 连佳, 肖时湘, 等. 载药微球与传统碘化油经肝动脉化疗栓塞术治疗不可切除肝癌效果比较的Meta分析[J]. 临床肝胆病杂志, 2019, 35(6): 1270-1275.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号