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HBV cccDNA转录调控机制与抗HBV治疗前景
Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy
文章发布日期:2019年05月13日  来源:  作者:陈娟,黄爱龙  点击次数:325次  下载次数:85次

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【摘要】:以微染色体形式存在的HBV共价闭合环状DNA(cccDNA)在肝细胞核内持续稳定的存在,被认为是HBV感染慢性化、抗病毒治疗无法清除病毒以及停药后肝炎复发的最主要原因。然而,现有各种抗病毒治疗方案中,缺少以cccDNA本身或形成、转录等环节为靶点的药物,因此,靶向cccDNA环节的治疗策略是急需填补的空白。随着对cccDNA微染色体上组蛋白表观遗传修饰的逐步解析,表观遗传治疗也有望成为HBV新的潜在治疗方向。主要关注了HBV DNA甲基化和cccDNA组蛋白修饰的研究现状和发展方向,试图为HBV表观遗传治疗提供思路。
【Abstract】:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is stably maintained in hepatocytes in the form of minichromosome and is considered the most important cause of chronicity of HBV infection, presence of HBV after antiviral therapy, and recurrence of hepatitis after drug withdrawal. However, due to a lack of antiviral regimens targeting cccDNA itself or the formation and transcription of cccDNA, there is an urgent need for treatment strategies targeting cccDNA. With the gradual understanding of epigenetic modification of histones of the cccDNA minichromosome, epigenetic therapy is expected to become a potential therapy for HBV. This article reviews the current status and future directions of HBV DNA methylation and cccDNA-bound histone modification, in order to provide new thoughts for epigenetic therapy for HBV.
【关键字】:乙型肝炎病毒; 基因调控网络; 共价闭合环状DNA; 基因, 修饰
【Key words】:hepatitis B virus; gene regulatory networks; cccDNA; genes, modifier
【引证本文】:CHEN J, HUANG AL. Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy[J]. J Clin Hepatol, 2019, 35(6): 1192-1196. (in Chinese)
陈娟, 黄爱龙. HBV cccDNA转录调控机制与抗HBV治疗前景[J]. 临床肝胆病杂志, 2019, 35(6): 1192-1196.

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