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肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析
Correlation between serum CA125 level and severity of liver dysfunction in patients with liver cirrhosis: A Meta-analysis
文章发布日期:2019年03月07日  来源:  作者:邵翠萍,徐有青  点击次数:318次  下载次数:82次

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【摘要】:目的探讨肝硬化患者血清CA125与肝功能损害程度的关系。方法检索万方科技期刊全文数据库、中国学术期刊(CNKI)全文数据库、中国生物医学文献数据库(CBM)、维普(VIP)中文科技期刊全文数据库于2008年1月-2018年10月发表的有关CA125与肝硬化患者肝损害程度相关性的中文文献,每篇文献均需设立肝硬化组及正常对照组。采用观察性流行病学研究报告规范(STROBE)为参考标准来评价入选文献质量。合并各文献肝硬化组和健康对照组、肝硬化组各Child-Pugh分级组CA125均数及标准差。采用Meta-Analyst 软件计算文献中各组CA125标准化均值差(SMD)进行Meta分析,对纳入的各研究进行异质性分析,如果各研究间存在显著异质性,则采用随机效应模型进行分析;如果各研究间异质性不显著,则采用固定效应模型进行分析。计量资料多组间比较采用单因素方差分析。结果共有15篇文献纳入研究。Meta分析结果显示,肝硬化组CA125水平显著高于健康对照组[(181.18±110.76)U/ml vs (15.10±7.15)U/ml],差异有统计学意义(SMD=2.28,95%可信区间:1.81~2.76,P<0001)。随着肝功能Child-Pugh分级升高,CA125水平也显著升高,差异具有统计学意义(F=15.704,P<0.001)。 结论肝硬化患者血清CA125水平与肝损害程度有相关性,对于评估肝硬化患者肝损害程度、判断预后具有一定的指导意义。
【Abstract】:ObjectiveTo investigate the correlation between serum CA125 level and the severity of liver dysfunction in patients with liver cirrhosis. MethodsWanfang Data, CNKI, CBM, and VIP were searched for Chinese articles on the correlation between serum CA125 level and the severity of liver dysfunction in patients with liver cirrhosis published from January, 2008 to October, 2018, with a liver cirrhosis group and a normal control group in each article. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) was used for quality assessment. The mean and standard deviation of CA125 in liver cirrhosis group, healthy control group, and liver cirrhosis groups with different Child-Pugh classes were analyzed. Meta-Analyst software was used to calculate the standardized mean deviation (SMD) of CA125 in each group and perform the meta-analysis. A heterogeneity analysis was performed for the studies included in this study; a random effects model was used in case of significant heterogeneity, while a fixed effect model was used in case of insignificant heterogeneity. A one-way analysis of variance was used for comparison of continuous data between multiple groups. ResultsA total of 15 articles were included in this study. The meta-analysis showed that the liver cirrhosis group had a significantly higher serum CA125 level than the healthy control group (181.18±110.76 U/ml vs 15.10±7.15 U/ml, SMD=2.28, 95% confidence interval: 1.81-2.76, P<0.001). The level of CA125 increased significantly with the increase in Child-Pugh class (F=15.704, P<0.001). ConclusionSerum CA125 level is correlated with the severity of liver dysfunction in patients with liver cirrhosis and thus has a certain value in evaluating the severity of liver dysfunction and predicting prognosis.
【关键字】:肝硬化; CA-125抗原; Child-Pugh分级; Meta分析
【Key words】:liver cirrhosis; CA-125 antigen; Child-Pugh grading; Meta-analysis
【引证本文】:SHAO CP, XU YQ. Correlation between serum CA125 level and severity of liver dysfunction in patients with liver cirrhosis: A Meta-analysis[J]. J Clin Hepatol, 2019, 35(4): 796-800. (in Chinese)
邵翠萍, 徐有青. 肝硬化患者血清CA125水平与肝损害程度相关性的Meta分析[J]. 临床肝胆病杂志, 2019, 35(4): 796-800.

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