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肝纤维化和肝硬化逆转的时代:现状与挑战
The era of the reversal of liver fibrosis and cirrhosis: Current status and challenges
文章发布日期:2019年03月07日  来源:  作者:王冰琼,孙亚朦,尤红  点击次数:263次  下载次数:150次

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【摘要】:越来越多的临床研究表明,有效的病因治疗可以逆转肝纤维化/早期肝硬化。纤维化逆转的准确评估对于治疗决策及判断预后具有重要价值。然而目前肝纤维化及肝硬化逆转的组织学 “金标准”仍待完善,肝纤维化逆转的无创评估仍有争议,能否改善临床硬终点尚需长期队列观察,同时抗纤维化新药的临床疗效尚有待进一步证实。
【Abstract】:An increasing number of clinical studies have shown that effective etiological therapy might achieve the reversal of liver fibrosis/early cirrhosis. An accurate assessment of fibrosis reversal is of great importance for treatment decision-making and prognosis prediction. At present, the “gold standard” for the histological evaluation of liver fibrosis/cirrhosis reversal remains to be perfected, and there is still a controversy over the noninvasive assessment of fibrosis reversal. Long-term cohort studies are needed to observe whether it can improve clinical hard endpoint, and the clinical effect of new anti-fibrotic drugs needs to be further confirmed.
【关键字】:肝硬化;生物学标记;活组织检查;述评
【Key words】:liver cirrhosis; biological markers; biopsy; editorial
【引证本文】:WANG BQ, SUN YM, YOU H. The era of the reversal of liver fibrosis and cirrhosis: Current status and challenges[J]. J Clin Hepatol, 2019, 35(4): 705-708. (in Chinese)
王冰琼, 孙亚朦, 尤红. 肝纤维化和肝硬化逆转的时代:现状与挑战[J]. 临床肝胆病杂志, 2019, 35(4): 705-708.

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