首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2019年 3期 酒精性肝炎的临床特点与处置策略 => 学术争鸣 =>重症酒精性肝炎与慢加..
重症酒精性肝炎与慢加急性肝衰竭
Severe alcoholic hepatitis and acute-on-chronic liver failure
文章发布日期:2019年02月03日  来源:  作者:孙福荣,王炳元  点击次数:156次  下载次数:52次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:酒精性肝炎(AH)患者出现以快速进展或加重的黄疸、凝血异常及肝脏相关并发症等为主的表现,往往提示发生重症AH的可能。在感染、大量饮酒等诱因的作用下,部分患者短期内病情迅速进展,不仅导致肝功能急性失代偿,并且出现以器官功能衰竭和较高的28 d病死率等为主要特征的慢加急性肝衰竭(ACLF)。早期识别ACLF并予以有效干预能够改善预后。肠道屏障功能障碍与肝-肠轴失衡在重症AH和ACLF的发展中发挥重要作用。应积极改善患者的营养状态,但药物治疗对改善ACLF病情和预后的作用有限。早期肝移植能够为患者带来更多获益。
【Abstract】:Rapid progression or aggravation of jaundice, coagulation abnormalities and liver-related complications in patients with alcoholic hepatitis indicates that they may develop severe alcoholic hepatitis. Some of these patients can progress acute-on-chronic liver failure with acute insults, such as infection and binge drinking and binge, showing as acute decompensation, organ failure and high 28-day mortality rate. Early identification and effective intervention can improve the prognosis of acute-on-chronic liver failure. Intestinal barrier dysfunction and liver-gut axis imbalance play an important role in the development of severe alcoholic hepatitis and acute-on-chronic liver failure. It is important to improve the basic nutritional status of patients. Effective drug therapies are limited in improving the condition and prognosis of acute-on-chronic liver failure. Early liver transplantation can bring great benefits to these patients.
【关键字】:肝炎, 酒精性; 慢加急性肝衰竭; 病理过程; 危险性评估; 治疗学
【Key words】:hepatitis, alcoholic; acute-on-chronic liver failure; pathologic processes; risk assessmen; therapeutics
【引证本文】:SUN FR, WANG BY. Severe alcoholic hepatitis and acute-on-chronic liver failure[J]. J Clin Hepatol, 2019, 35(3): 489-493. (in Chinese)
孙福荣, 王炳元. 重症酒精性肝炎与慢加急性肝衰竭[J]. 临床肝胆病杂志, 2019, 35(3): 489-493.

相关文章
地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号