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您现在的位置:首页 => 在线期刊 => 2019年 2期 胆汁淤积性肝病诊治的基础与临床 => 综述 =>胆汁淤积动物模型的应..
胆汁淤积动物模型的应用现状
Establishment and application of animal models of cholestasis
文章发布日期:2019年01月07日  来源:  作者:杜丽娜,杨燕  点击次数:271次  下载次数:40次

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【摘要】:胆汁淤积性肝病是1岁以内儿童常见病之一,其病因复杂,预后不一,为进一步深入研究其发病机制及治疗策略,研究者建立了多种不同的胆汁淤积动物模型。如通过手术或外界物理化学损伤建立梗阻型胆汁淤积模型;通过化学药品或内毒素诱导建立肝内胆汁淤积模型,包括α-萘异硫氰酸酯、脂多糖、3,5-二乙氧基羰基-1,4-二氢三甲基吡啶、雌激素、氯丙嗪、利福平、石胆酸等;或通过肠道损伤与肠外营养相结合建立肠外营养相关胆汁淤积模型。各类模型体现了不同的病因和发展过程。现对医学研究中较常用的胆汁淤积动物模型特点及机理、适应证作一综述。
【Abstract】:Cholestatic liver disease is one of the common diseases in children aged <1 year and has a complex etiology and different outcomes. Various animal models have been established to further investigate the pathogenesis of cholestatic liver disease and related treatment strategies. A model of obstructive cholestasis is established by surgery or external physical and chemical damage; a model of intrahepatic cholestasis is induced by chemicals or endotoxins, including α-naphthyl isothiocyanate, lipopolysaccharide, 3,5-diethoxycarbonyl-1,4-dihydrocollidine, estrogen, chlorpromazine, rifampicin, and lithocholic acid; a model of parenteral nutrition-associated cholestasis is established by a combination of intestinal damage and parenteral nutrition. These models reflect different causes and development processes. This article reviews the characteristics, mechanisms, and indications of animal models of cholestasis commonly used in medical research.
【关键字】:胆汁淤积; 模型, 动物; 综述
【Key words】:cholestasis; models, animal; review
【引证本文】:DU LN, YANG Y. Establishment and application of animal models of cholestasis[J]. J Clin Hepatol, 2019, 35(2): 444-447. (in Chinese)
杜丽娜,杨燕. 胆汁淤积动物模型的构建及应用前景[J]. 临床肝胆病杂志, 2019, 35(2): 444-447.

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