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胆汁酸的肝肠循环及肠道微生态在胆汁淤积性肝病发病和治疗中的作用
The role of enterohepatic circulation of bile acids and intestinal microbiota in the pathogenesis and treatment of cholestatic liver disease
文章发布日期:2019年01月07日  来源:  作者:贾昊宇,杨长青  点击次数:631次  下载次数:206次

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【摘要】:胆汁淤积性肝病是指由病毒、细菌、寄生虫、药物、毒物、自身免疫、酒精、结石、肿瘤和遗传代谢等一系列原因导致胆汁淤积发生而引起的肝脏疾病,主要表现为胆汁流量的改变和胆汁酸毒性的过度积累。在胆汁淤积性肝病的发病过程中,不仅有内源性胆汁酸的肝肠循环作用的参与,且肠道微生物群也通过调节代谢和免疫反应发挥重要作用。除此之外,肠道微生物群与胆汁酸的肝肠循环之间也存在密切的相互作用。胆汁酸可以改变肠道微生物群的组成,反之,肠道微生物也能够影响胆汁酸池。近年来针对胆汁酸的肝肠循环、肠道微生物群与胆汁淤积性肝病之间关系的研究日渐深入,为胆汁淤积性肝病的发病机制及治疗方法提供了一些新的研究方向。
【Abstract】:Cholestatic liver disease refers to a liver disorder caused by cholestasis, which arise from a series of etiologies such as viruses, bacteria, parasites, drugs, poisons, autoimmunity, alcohol, stones, tumors, genetics, and metabolism. This disease has the main manifestations of a change in bile flow and excessive accumulation of bile acid toxicity. In the pathogenesis of cholestatic liver disease, not only does the enterohepatic circulation of endogenous bile acids work, but also the intestinal microbiota plays an important role by regulating metabolism and causing immune responses. In addition, more attention has been paid to the close interaction between intestinal microbiota and the enterohepatic circulation of bile acids. Bile acids can alter the composition of intestinal microbiota, which in turn affects the bile acid pool. In recent years, there has been increasing research on the relationship of the enterohepatic circulation of bile acids and intestinal microbiota with cholestatic liver disease, which may provide new research directions for the pathogenesis and treatment of cholestatic liver disease.
【关键字】:胆汁淤积; 胆酸类; 肝肠循环; 肠道微生物群
【Key words】:cholestasis; cholic acids; enterohepatic circulation; intestinal microbiota
【引证本文】:JIA HY, YANG CQ. The role of enterohepatic circulation of bile acids and intestinal microbiota in the pathogenesis and treatment of cholestatic liver disease[J]. J Clin Hepatol, 2019, 35(2): 270-274. (in Chinese)
贾昊宇,杨长青. 胆汁酸的肝肠循环及肠道微生态在胆汁淤积性肝病发病和治疗中的作用[J]. 临床肝胆病杂志, 2019, 35(2): 270-274.

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