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胆汁淤积性肝病的诊治现状及研究方向
Current status and research interests of the diagnosis and treatment of cholestatic liver disease
文章发布日期:2019年01月07日  来源:  作者:于乐成,陈成伟  点击次数:393次  下载次数:201次

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【摘要】:胆汁淤积性肝病(CSLD)是指能够引起胆汁淤积的多种肝病的集合和统称,其病因复杂,发病机制有待深入阐明,尚缺乏足够有效的治疗手段。近十余年来对CSLD的多个方面有了较多新认识,为其精准诊治提供了更多层面和更为有效的抓手,同时也反映了许多问题依然悬而未决,亟需继续深入研究。本期重点号从6大方面介绍了有关CSLD的研究进展和存在问题:(1)CSLD的“上升”病理生理学模式;(2)胆汁淤积导致肝纤维化的机制及处置对策;(3)肠肝循环和肠道微生态与CSLD的关系;(4)药物性胆汁淤积的发病机制和诊疗问题;(5)肝衰竭时胆汁淤积的发生机制及处置对策;(6)胆汁淤积性肝病的治疗靶点和药物研发进展等。
【Abstract】:Cholestatic liver disease (CSLD) is a group of liver diseases which can cause cholestasis and has a complex etiology. Its pathogenesis remains unclear, and there are still no effective treatment measures. In the recent decade, new achievements have been made on various aspects of CSLD, which provides more help to accurate diagnosis and treatment and reflects many pending issues which need further research. This article introduces the research advances and problems in CSLD from the following six aspects: the “ascending” pathophysiology of CSLD, mechanisms of cholestasis-induced liver fibrosis and related management measures, association of enterohepatic circulation and intestinal microbiota with CSLD, pathogenesis and diagnosis/treatment of drug-induced cholestasis, pathogenesis and management of liver failure-associated cholestasis, and research advances in treatment targets and drug research and development for CSLD.
【关键字】:胆汁淤积; 肝硬化; 肠肝循环; 肝功能衰竭; 诊断; 治疗学; 述评
【Key words】:cholestasis; liver cirrhosis; enterohepatic circulation; liver failure; diagnosis; therapeutics; editorial
【引证本文】:YU YC, CHEN CW. Current status and research interests of the diagnosis and treatment of cholestatic liver disease[J]. J Clin Hepatol, 2019, 35(2): 241-246. (in Chinese)
于乐成, 陈成伟. 胆汁淤积性肝病的诊治现状及研究方向[J]. 临床肝胆病杂志, 2019, 35(2): 241-246.

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