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【摘要】：细胞自噬作为一种双向性的肿瘤调节因子，对胰腺癌发生、发展，乃至治疗过程起着非常重要的作用；而神经浸润作为一种特殊的肿瘤转移通路，在胰腺癌中的发生率极高，与胰腺癌手术后高复发率和胰腺癌相关疼痛密切相关。简述了胰腺癌细胞自噬与神经浸润的研究进展，以期对胰腺癌的诊断和治疗提供新的研究思路。
【Abstract】：As a bi-directional tumor regulatory factor, autophagy plays an important role in the development, progression, and treatment of pancreatic cancer. Perineural invasion, a special pathway for tumor metastasis, has a high incidence rate in pancreatic cancer and is closely associated with high recurrence rate after pancreatic cancer surgery and pancreatic cancer-related pain. This article summarizes the research advances in the role of autophagy and perineural invasion in pancreatic cancer, so as to provide new research ideas for the diagnosis and treatment of pancreatic cancer.
【关键字】：胰腺肿瘤； 自噬； 神经浸润； 综述
【Key words】：pancreatic neoplasms； autophagy； perineural invasion； review
【引证本文】：YANG YH, ZHANG YX, GUI Y, et al. Research advances in the role of autophagy and perineural invasion in pancreatic cancer［J］. J Clin Hepatol, 2018, 34(11): 2475-2479. (in Chinese) 杨延辉， 张玉祥， 桂洋， 等. 胰腺癌与自噬、神经浸润的关系［J］. 临床肝胆病杂志, 2018, 34(11): 2475-2479.