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肝硬化异常脾脏对肝脏病理生理功能的影响
Influence of abnormal spleen on liver pathophysiological function in patients with liver cirrhosis
文章发布日期:2018年09月30日  来源:  作者:江晓妮,刘敏,李强,等  点击次数:204次  下载次数:32次

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【摘要】:脾肿大是肝硬化门静脉高压较早出现的体征。由于肝硬化时脾静脉回流阻力增加,门静脉压力逆传至脾脏,使脾脏被动淤血性肿大,脾组织和脾内纤维组织增生。此外,肠道抗原物质经门-体侧支循环进入体循环,被脾脏摄取后抗原刺激脾单核-巨噬细胞增生,引发脾肿大、脾功能亢进。反之,异常脾脏也可以导致肝功能和门静脉血流动力学改变。因此,在肝硬化及其并发症的治疗过程中,对脾脏的干预是不容忽视的环节。综述了肝硬化过程中脾脏结构与功能异常对肝脏病理生理功能的影响。
【Abstract】:Splenomegaly is an early sign of cirrhotic portal hypertension. In patients with liver cirrhosis, the resistance of splenic venous reflux increases and portal venous pressure is reversed to the spleen, which causes congestive splenomegaly and hyperplasia of splenic tissue and fibrous tissue. In addition, intestinal antigens enter the systemic circulation via the portal-systemic collateral circulation and stimulates the proliferation of mononuclear macrophages in the spleen after being taken up by the spleen, which further leads to splenomegaly and hypersplenism. On the contrary, abnormal spleen can cause the changes in liver function and portal vein hemodynamics. Therefore, the intervention of the spleen cannot be neglected during the treatment of liver cirrhosis and its complications. This article reviews the influence of abnormal spleen structure and function on liver pathophysiological function in patients with liver cirrhosis.
【关键字】:肝硬化; 高血压, 门静脉; 脾大; 脾功能亢进; 综述
【Key words】:liver cirrhosis; hypertension, portal; splenomegaly; hypersplenism; review
【引证本文】:JIANG XN, LIU M, LI Q, et al. Influence of abnormal spleen on liver pathophysiological function in patients with liver cirrhosis[J]. J Clin Hepatol, 2018, 34(11): 2420-2423. (in Chinese) 江晓妮, 刘敏, 李强, 等. 肝硬化异常脾脏对肝脏病理生理功能的影响[J]. 临床肝胆病杂志, 2018, 34(11): 2420-2423.

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