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Wnt信号通路与肝纤维化发生发展的关系
Role of the Wnt signaling pathway in the development and progression of liver fibrosis
文章发布日期:2018年09月30日  来源:  作者:赵东康, 骆伟伟, 余水平  点击次数:216次  下载次数:27次

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【摘要】:肝纤维化的发生发展机制复杂,包含众多细胞内外信号转导通路,但其具体机制尚未明确。最近较多研究证实Wnt信号通路异常激活进而使肝星状细胞活化是导致肝纤维化的重要原因;靶向抑制Wnt信号通路能够阻止肝星状细胞的活化、增殖,从而达到抗纤维化的目的。对Wnt信号通路在肝纤维化发生和发展中的作用以及干扰Wnt信号通路抗肝纤维化的最新研究进展进行综述,期望为抗肝纤维化和延缓早期肝硬化提供新的思路。
【Abstract】:Liver fibrosis has a complex pathogenesis and involves various intracellular and extracellular signal transduction pathways, but its specific pathogenesis remains unclear. Recent studies have confirmed that the activation of hepatic stellate cells due to abnormal activation of the Wnt signaling pathway is an important cause of liver fibrosis, and targeted inhibition of the Wnt signaling pathway can prevent the activation and proliferation of hepatic stellate cells and thus achieve an antifibrogenic effect. This article reviews the role of the Wnt signaling pathway in the development and progression of liver fibrosis and the latest research advances in the antifibrogenic effect of the interference of the Wnt signaling pathway, in order to provide new ideas for anti-hepatic fibrosis and the delay of early-stage cirrhosis.
【关键字】:肝硬化; 脂细胞; 信号传导; 综述
【Key words】:liver cirrhosis; adipocytes; signal transduction; review
【引证本文】:ZHAO DK, LUO WW, YU SP. Role of the Wnt signaling pathway in the development and progression of liver fibrosis[J]. J Clin Hepatol, 2018, 34(11): 2415-2419. (in Chinese) 赵东康, 骆伟伟, 余水平. Wnt信号通路与肝纤维化发生发展的关系[J]. 临床肝胆病杂志, 2018, 34(11): 2415-2419.

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