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非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素
Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis
文章发布日期:2018年09月10日  来源:  作者:陈艳珍,陈成良,洪宇,等  点击次数:267次  下载次数:20次

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【摘要】:目前,非酒精性脂肪性肝病(NAFLD)已经成为全球慢性肝病的主要病因,是隐源性肝硬化的常见致病因素。临床上,NAFLD患者多见于肥胖群体,但非肥胖人群中NAFLD亦不罕见,尤其是亚洲人群。非肥胖型NAFLD与肥胖型NAFLD代谢谱相当,但最近多项研究显示与肥胖型NAFLD相比,非肥胖型肝纤维化、肝硬化有其独特的特点。回顾了近年来非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素,以期更好地了解该病的预防、诊断和治疗。
【Abstract】:At present, non-alcoholic fatty liver disease (NAFLD) has become the major cause of chronic liver disease in the world and is considered a common pathogenic factor of cryptogenic cirrhosis. In clinical practice, NAFLD is commonly seen in obese patients; however, it is not rare among non-obese individuals, especially in the Asian population. Non-obese NAFLD patients have similar metabolic profiles to obese NAFLD patients, but many studies have revealed that compared with obese NAFLD, non-obese liver fibrosis and liver cirrhosis have unique features. This article reviews the research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis in recent years, in order to gain a better understanding of the prevention, diagnosis, and treatment of this disease.
【关键字】:非酒精性脂肪性肝病; 肝硬化; 综述
【Key words】:non-alcoholic fatty liver; liver cirrhosis; review
【引证本文】:CHEN YZ, CHEN CL, HONG Y, et al. Research advances in the pathogenesis and risk factors of non-obese non-alcoholic fatty liver fibrosis and liver cirrhosis[J]. J Clin Hepatol, 2018, 34(10): 2227-2231. (in Chinese)
陈艳珍, 陈成良, 洪宇, 等. 非肥胖型非酒精性脂肪性肝纤维化、肝硬化的发病机制及危险因素[J]. 临床肝胆病杂志, 2018, 34(10): 2227-2231.

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