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HBV DNA载量对乙型肝炎相关肝癌手术治疗效果的影响
Influence of HBV DNA load on surgical outcome of hepatitis B-associated liver cancer
文章发布日期:2018年09月09日  来源:  作者:叶海雯, 邓勇, 张灵强, 等  点击次数:411次  下载次数:63次

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【摘要】:HBV感染在我国高度流行,长期HBV DNA高载量患者可进展为肝硬化进而导致肝癌的发生。目前,手术仍是治疗乙型肝炎相关肝癌的主要方法。大量研究表明,HBV DNA载量是影响乙型肝炎相关肝癌患者术后肝功能恢复、术后并发症的发生、肝癌复发及肝移植是否成功的重要因素。其机制可能与高HBV DNA载量和HBV再激活相关。通过抗病毒治疗使HBV DNA载量保持一定的低水平状态可改善乙型肝炎相关肝癌患者的预后。综述了术前、术后不同HBV DNA载量对乙型肝炎相关肝癌手术治疗效果的影响,旨在为研究治疗肝癌患者提供参考。
【Abstract】:HBV infection is highly prevalent in China, and patients with a high HBV-DNA load for a long time may progress to liver cirrhosis, which may lead to liver cancer. At present, surgery is still the main method for the treatment of hepatitis B-related liver cancer. Many studies have shown that HBV DNA load is an important influencing factor for the recovery of liver function after surgery, postoperative complications, recurrence of liver cancer, and the success of liver transplantation in patients with hepatitis B-related liver cancer. Its mechanism may be associated with high HBV DNA load and HBV reactivation. Maintaining a low HBV DNA load by antiviral therapy can improve the prognosis of patients with hepatitis B-related liver cancer. This article reviews the influence of HBV DNA load before and after surgery on the surgical outcome of hepatitis B-related liver cancer, in order to provide a reference for research on the treatment of patients with liver cancer.
【关键字】:病毒载量; 肝炎,乙型; 肝肿瘤; 外科手术; 治疗结果
【Key words】:viral load; hepatitis B; liver neoplasms; surgical procedures, operative; treatment outcome
【引证本文】:YE HW, DENG Y, ZHANG LQ, et al. Influence of HBV DNA load on surgical outcome of hepatitis B-associated liver cancer[J]. J Clin Hepatol, 2018, 34(9): 1995-1998. (in Chinese)
叶海雯, 邓勇, 张灵强, 等. HBV DNA载量对乙型肝炎相关肝癌手术治疗效果的影响[J]. 临床肝胆病杂志, 2018, 34(9): 1995-1998.

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