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海口地区体检人群非酒精性脂肪性肝病患病率调查分析
An investigation of the prevalence rate of nonalcoholic fatty liver disease in the population undergoing physical examination in Haikou, China
文章发布日期:2018年08月06日  来源:  作者:阮建文,高丽娟,梁雄飞,等  点击次数:169次  下载次数:13次

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【摘要】:目的了解海口地区非酒精性脂肪性肝病 (NAFLD) 的流行现状, 分析NAFLD与代谢综合征及其相关组分的关系。方法选取2016年9月-2017年8月在海口市人民医院进行健康体检者18 771例, 测量身高、体质量、血压、空腹血糖、血脂、肝功能等指标, 行肝脏B超检查。计算NAFLD的患病率, 分析NAFLD与代谢综合征及其相关组分的关系。计量资料2组间比较采用t检验;计数资料组间比较采用χ2检验。结果18771例体检对象中NAFLD 5715例, 患病率为30.45%;男性NAFLD患病率为4174%,女性NAFLD患病率为17.22%。男性NAFLD患病高峰年龄为45~59岁,女性NAFLD患病高峰年龄为45岁及以上。男性中度NAFLD患病率高于女性(8.10% vs 1.19%, χ2=476.1,P<0.001)。男性人群中肥胖、超重者的NAFLD患病率较高,女性人群中肥胖者NAFLD患病率较高,男性和女性中不同BMI水平组的NAFLD患病率差异均有统计学意义(χ2值分别为2111、1917,P值均<0.001)。NAFLD患者BMI、血压、FPG、TG、ALT、AST、GGT明显高于非NAFLD者,而HDL明显降低,差异均有统计学意义(t值分别为41.276、32339、31.487、12.185、9.716、38.382、26.350、25.291、15.008,P值均<0.001)。结论海口地区体检人群NAFLD患病率较高, 男性患病率高于女性;NAFLD代谢综合征及其相关组分关系密切。
【Abstract】:ObjectiveTo investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) in Haikou, China and the association of NAFLD with metabolic syndrome (MS) and its components. MethodsA total of 18771 persons who underwent physical examination in Haikou People’s Hospital from September 2016 to August 2017 were enrolled. Body height, body weight, blood pressure, fasting plasma glucose, blood lipids, and liver function parameters were measured, and ultrasound examination was performed for the liver. The prevalence rate of NAFLD was calculated, and the association of NAFLD with MS and its components was analyzed. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. ResultsOf all 18771 persons, 5715 had NAFLD, resulting in a prevalence rate of 30.45%; the prevalence rate of NAFLD was 41.74% in men and 1722% in women. Men aged 45-59 years had the highest prevalence rate of NAFLD, and women aged ≥45 years had the highest prevalence rate. Men had a significantly higher prevalence rate of moderate NAFLD than women (8.10% vs 1.19%, χ2=476.1, P<0.001). Men with obesity and overweight had a higher prevalence rate of NAFLD, and women with obesity had a higher prevalence rate; in both men and women, there was a significant difference in the prevalence rate of NAFLD between groups with different levels of body mass index (BMI) (χ2=2111,1917,all P<0.001). NAFLD patients had significantly higher BMI, blood pressure, fasting plasma glucose, triglyceride, alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase than non-NAFLD patients (t=41.276, 32.339, 31.487, 12.185, 9.716, 38.382, 26.350, 25.291, and 15.008, all P<0.001). ConclusionThere is a high prevalence rate of NAFLD in people undergoing physical examination in Haikou, and men tend to have a higher prevalence rate than women. NAFLD is closely associated with MS and its components.
【关键字】:非酒精性脂肪性肝病; 代谢综合征X; 海口
【Key words】:nonalcoholic fatty liver disease; metabolic syndrome X; HAIKOU
【引证本文】:RUAN JW, GAO L, LIANG XF, et al. An investigation of the prevalence rate of nonalcoholic fatty liver disease in the population undergoing physical examination in Haikou, China[J]. J Clin Hepatol, 2018, 34(9): 1925-1928. (in Chinese)
阮建文, 高丽娟, 梁雄飞, 等. 海口地区体检人群非酒精性脂肪性肝病患病率调查分析[J]. 临床肝胆病杂志, 2018, 34(9): 1925-1928.

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