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肝衰竭并发急性肾损伤热点研究新进展
Advances in research hotspots in liver failure complicated by acute kidney injury
文章发布日期:2018年08月06日  来源:  作者:庄焱,谢青  点击次数:280次  下载次数:51次

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【摘要】:急性肾损伤(AKI)定义为肾小球滤过率急剧下降和血清肌酐的急骤升高,是肝衰竭患者的严重并发症之一。早期诊断及处理对降低病死率、改善肝衰竭预后极为重要。对肝衰竭患者AKI的诊断标准、发病机制、生物标志物、临床特点及治疗的研究进展进行阐述。指出对AKI的定义、分期不断修正,研发高效的肾损伤生物标记物,是未来研究的方向。
【Abstract】:Acute kidney injury (AKI) is defined as a sharp drop in glomerular filtration rate (GFR) and a rapid increase in serum creatinine and is one of the most serious complications of liver failure. Early diagnosis and treatment play a vital role in reducing the mortality and improving the prognosis of liver failure. This article elaborates on the research advances in the diagnostic criteria, pathogenesis, biomarkers, clinical features, and treatment of AKI and points out that constant modification of the definition and staging of AKI and research and development of efficient biomarkers for AKI are future research directions.
【关键字】:肝功能衰竭; 肾功能不全, 急性; 诊断; 治疗学; 生物学标记
【Key words】:liver failure; renal insufficiency, acute; diagnosis; therapeutics; biological markers
【引证本文】:ZHUANG Y, XIE Q. Advances in research hotspots in liver failure complicated by acute kidney injury[J]. J Clin Hepatol, 2018, 34(9): 1836-1841. (in Chinese)
庄焱, 谢青. 肝衰竭并发急性肾损伤热点研究新进展[J]. 临床肝胆病杂志, 2018, 34(9): 1836-1841.

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