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2型糖尿病与肝细胞癌的关系
The association between type 2 diabetes mellitus and hepatocellular carcinoma
文章发布日期:2018年07月06日  来源:  作者:游宇来,邓明华,龚建平  点击次数:244次  下载次数:51次

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【摘要】:2型糖尿病与肝细胞癌的发生有密切联系。2型糖尿病可能通过多种方式增加肝细胞癌发病风险,表明两种疾病的发病过程中可能存在共同的信号通路或易感基因。探讨了2型糖尿病影响HCC发生的机制及两者在基因及分子水平的关系,发现核受体辅激活蛋白5、转录因子7类似物2、糖原合成酶激酶3β和Toll样受体4均参与了2型糖尿病和肝细胞癌的发病过程,是将这两种疾病在基因和分子水平联系起来的关键。
【Abstract】:Type 2 diabetes mellitus (T2DM) is closely associated with the development of hepatocellular carcinoma (HCC). T2DM can increase the risk of HCC in many ways, which suggests that several signaling pathways or susceptibility genes might be involved in the development of these two diseases. This article discusses the role of T2DM in the development of HCC and the association between T2DM and HCC at genetic and molecular levels and finds that nuclear receptor co-activator 5, transcription factor 7-like 2, glycogen synthase kinase 3β, and Toll-like receptor 4 are involved in the pathogenesis of T2DM and HCC, which is the key that links the two diseases at genetic and molecular levels.
【关键字】:癌, 肝细胞; 糖尿病, 2型; 综述
【Key words】:carcinoma, hepatocellular; diabetes mellitus, type 2; review
【引证本文】:YOU YL, DENG MH, GONG JP. The association between type 2 diabetes mellitus and hepatocellular carcinoma [J]. J Clin Hepatol, 2018, 34(8): 1793-1796. (in Chinese)
游宇来, 邓明华, 龚建平. 2型糖尿病与肝细胞癌的关系[J]. 临床肝胆病杂志, 2018, 34(8): 1793-1796.

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