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岩藻糖基化高尔基体蛋白73在小肝癌早期诊断中的价值
Clinical value of fucosylated Golgi protein 73 in differential diagnosis of small hepatocellular carcinoma
文章发布日期:2018年07月06日  来源:  作者:赵运胜,张丽娜,霍丽静,等  点击次数:316次  下载次数:61次

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【摘要】:目的探讨血清岩藻糖基化高尔基体蛋白73(Fuc-GP73)在鉴别诊断低浓度AFP原发性小肝癌(sHCC)中的临床价值。方法选取2014年4月-12月秦皇岛市第一医院患者及体检中心健康者共150例,其中低浓度AFP sHCC患者50例(sHCC组),慢性乙型肝炎患者20例(CHB组),肝硬化患者20例(LC组),除肝癌外其他消化系统恶性肿瘤患者20例(MTDS组),健康对照者40例(NC组)。应用凝集素亲和层析柱联合ELISA法检测血清中Fuc-GP73含量。计量资料多组间比较采用Kruskal-Wallis H检验,进一步两两比较采用Nemenyi检验;计数资料多组间比较采用χ2检验。绘制受试者工作特征曲线(ROC曲线)评价Fuc-GP73检测对sHCC的诊断价值。采用logistic回归分析预测模型评价各标志物联合检测的诊断效果。结果各组Fuc-GP73水平差异有统计学意义(H=87.225,P=0.001),其中sHCC患者Fuc-GP73水平明显高于其他组(P值均<0.05);Fuc-GP73在sHCC组、CHB组、LC组、MTDS组和NC组的阳性检出率分别为80%(40/50)、0(0/20)、20%(4/20)、5% (1/20)、0(0/40),各组间比较差异有统计学意义(χ2=92.143,P<0.01),其中sHCC组Fuc-GP73阳性检出率明显高于其他组(P值均<0.01)。Fuc-GP73检测sHCC的敏感度、特异度、准确度和ROC曲线下面积分别为80.0%、95.0%、90.0%和0.892;与其他多种标志物联合检测sHCC的敏感度、特异度、准确度和ROC曲线下面积可达96.0%、98.0%、97.3%和0.991。结论Fuc-GP73可作为一种新的优于AFP的sHCC检测的糖基化肿瘤标志物。
【Abstract】:ObjectiveTo investigate the clinical value of serum fucosylated Golgi protein 73 (Fuc-GP73) in the differential diagnosis of small hepatocellular carcinoma (sHCC) with a low level of alpha-fetoprotein (AFP). MethodsA total of 110 patients who were treated in Qinhuangdao First Hospital from April to December, 2014 were enrolled, and among these patients, 50 had sHCC with a low level of AFP (sHCC group), 20 had chronic hepatitis B (CHB group), 20 had liver cirrhosis (LC group), and 20 had malignant tumor in the digestive system except liver cancer (MTDS group). A total of 40 individuals who underwent physical examination in our hospital were enrolled as normal controls (NC group). Lectin affinity chromatography and ELISA were used to measure the serum level of Fuc-GP73. The Kruskal-Wallis H test was used for comparison of continuous data between multiple groups, and the Nemenyi test was used for further comparison between two groups; the chi-square test was used for comparison of categorical data between groups. The receiver operating characteristic (ROC) curve was plotted to analyze the value of Fuc-GP73 in the diagnosis of sHCC. The logistic regression model was used to evaluate the diagnostic efficiency of the combined measurement of Fuc-GP73 and other markers. ResultsThere was a significant difference in the level of Fuc-GP73 between groups (H=87.225, P=0.001), and the sHCC group had a significantly higher level than the other groups (all P<0.05). The detection rate of Fuc-GP73 was 80% (40/50) in the sHCC group, 0 (0/20) in the CHB group, 20% (4/20) in the LC group, 5% (1/20) in the MTDS group, and 0 (0/40) in the NC group; there was a significant difference between groups (χ2=92.143, P<0.01), and the sHCC group had a significantly higher detection rate than the other groups (all P<0.01). In the diagnosis of sHCC, Fuc-GP73 had a sensitivity of 80.0%, a specificity of 95.0%, an accuracy rate of 90.0%, and an area under the ROC curve of 0.892, and the combined measurement of Fuc-GP73 and other markers had a sensitivity of 96.0%, a specificity of 98.0%, an accuracy rate of 97.3%, and an area under the ROC curve of 0.991. ConclusionFuc-GP73 can be used as a glycosylated tumor marker for sHCC and is better than AFP.
【关键字】:癌, 肝细胞; 高尔基体蛋白73; 糖基化; 早期诊断
【Key words】:
【引证本文】:ZHAO YS, ZHANG LN, HUO LJ, et al. Clinical value of fucosylated Golgi protein 73 in differential diagnosis of small hepatocellular carcinoma[J]. J Clin Hepatol, 2018, 34(8): 1707-1711. (in Chinese)
赵运胜, 张丽娜, 霍丽静, 等. 岩藻糖基化高尔基体蛋白73在小肝癌早期诊断中的价值[J]. 临床肝胆病杂志, 2018, 34(8): 1707-1711.

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