首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 7期肝癌的诊断和治疗 => 综述 =>辅助性T淋巴细胞17和调节性T淋巴细胞及..
辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与自身免疫性肝炎的关系
Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis
文章发布日期:2018年06月07日  来源:  作者:葛宽雪,高伟华,向晓星  点击次数:262次  下载次数:32次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:自身免疫性肝炎是一种肝脏慢性炎症性疾病,其病因及发病机制尚未阐明。近年来,免疫调节异常机制成为研究热点之一。调节性T淋巴细胞(Treg)及辅助性T淋巴细胞(Th)17是CD4+T淋巴细胞的2个亚群,在功能、分化等方面有明显的差异,其平衡状态对于确保自身免疫系统的稳定发挥着重要作用,若两者出现失衡必然会造成免疫应答失常,导致自身免疫性疾病。深入研究Treg和Th17在自身免疫性肝炎中的发病机制,将为该病的免疫治疗提供新策略。就Treg和Th17在自身免疫性肝炎中的平衡变化作一综述。
【Abstract】:Autoimmune hepatitis (AIH) is a chronic liver inflammatory disease, and its etiology and pathogenesis remain unclear. In recent years, abnormal immune regulation mechanism has become a research hotspot. Regulatory T (Treg) cells and Th17 cells are two subsets of CD4+ T cells and there are significant differences in function and differentiation between them. Treg/Th17 balance plays an important role in maintaining the stability of human immune system, and Treg/Th17 imbalance will cause abnormal immune response and then lead to autoimmune diseases. In-depth studies on the role of Treg and Th17 cells in the pathogenesis of AIH may provide new strategies for immunotherapy for this disease. This article reviews the change in Treg/Th17 balance in autoimmune hepatitis.
【关键字】:肝炎,自身免疫性;T淋巴细胞,调节性;T淋巴细胞,辅助诱导;综述
【Key words】:hepatitis, autoimmune; T-lymphocytes, regulatory; T-lymphocytes, helper-inducer; review
【引证本文】:GE KX, GAO WH, XIANG XX. Association of regulatory T cells, T helper 17 cells, and change in their balance with autoimmune hepatitis[J]. J Clin Hepatol, 2018, 34(7): 1573-1576. (in Chinese)
葛宽雪, 高伟华, 向晓星. 辅助性T淋巴细胞17和调节性T淋巴细胞及其平衡改变与自身免疫性肝炎的关系[J]. 临床肝胆病杂志, 2018, 34(7): 1573-1576.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号