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糖皮质激素治疗肝衰竭研究现状
Research advances in glucocorticoids for the treatment of liver failure
文章发布日期:2018年06月07日  来源:  作者:王秀芳,冯国和  点击次数:326次  下载次数:75次

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【摘要】:糖皮质激素(GCs)由于其抗炎和免疫抑制作用而广泛应用于伴有炎症状态的肝病治疗中,尤其应用于自身免疫性肝炎及淤胆型肝炎。但是国内外学者对于GCs是否应用于肝衰竭的治疗尚存在争议。一方面,有学者认为GCs可抑制免疫,导致免疫功能紊乱,诱发细菌及真菌感染,进而增加病死率;另一方面,也有学者认为其可抑制免疫应答、减轻炎症反应、减少肝细胞坏死,发挥保护肝细胞、延长生存周期的作用。综述了GCs治疗肝衰竭的机制,应用时机、剂量,不同病因肝衰竭中GCs的应用以及应用期间的观察指标等研究现状。
【Abstract】:Glucocorticoids (GCs) are widely used in the treatment of liver diseases accompanied by inflammation due to its strong anti-inflammatory and immunosuppressive effects, especially autoimmune hepatitis and cholestatic hepatitis. However, there are still controversies over the use of GCs in the treatment of liver failure among Chinese and foreign scholars. On the one hand, some scholars think that GCs can suppress immune function, cause immune dysfunction, induce bacterial and fungal infections, and thus increase mortality; on the other hand, some scholars believe that GCs can suppress immune response, reduce inflammatory response and hepatocyte necrosis, and thus protect hepatocytes and prolong survival. This article reviews the mechanism, opportune administration, and dosage of GCs in the treatment of liver failure, as well as the current status of the research on the application of GCs in liver failure of different etiologies and observation indices during application.
【关键字】:糖皮质激素类;肝功能衰竭;治疗;综述
【Key words】:glucocorticoids; liver failure; therapy; review
【引证本文】:WANG XF, FENG GH. Research advances in glucocorticoids for the treatment of liver failure[J]. J Clin Hepatol, 2018, 34(7): 1565-1568. (in Chinese)
王秀芳, 冯国和. 糖皮质激素治疗肝衰竭研究现状[J]. 临床肝胆病杂志, 2018, 34(7): 1565-1568.

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