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实验室常见检测指标对肝细胞癌预后预测价值的思考
Value of common laboratory parameters in predicting the prognosis of hepatocellular carcinoma
文章发布日期:2018年06月07日  来源:  作者:文夏杰,姚明解,张玲,等  点击次数:842次  下载次数:153次

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【摘要】:肝细胞癌(HCC)患者多有基础肝病,与其他癌症不同,HCC患者的肿瘤特征及残存肝功能均会影响到患者术后生存。为了帮助临床医生确定能够在根治性肝切除术中获益的患者,结合实验室前期研究及文献回顾,总结了对HCC患者预后有指导意义的常见临床检测指标。其中特别介绍了反映肝脏合成功能的血清学指标前白蛋白,其作为HCC患者术后独立预后因素被纳入传统Child-Pugh肝功能评价系统,形成改良的肝功能评分系统,可更加精确预测根治性肝切除术后患者的预后。这一评分系统或将有助于更加精准地选择适宜接受手术的HCC患者。
【Abstract】:Patients with hepatocellular carcinoma (HCC) often have underlying liver diseases, and unlike other types of cancer, the features of HCC and residual liver function may affect patient survival after surgery. In order to help clinicians identify patients who can benefit from radical hepatectomy, this article summarizes common laboratory parameters which have guiding significance for the prognosis of HCC patients, with reference to preliminary laboratory studies and literature review. This article particularly introduces prealbumin, a serological marker which reflects liver synthetic function, and as an independent prognostic factor for HCC patients after surgery, prealbumin is integrated into the traditional Child-Pugh classification system to develop a modified liver function scoring system, which can accurately predict the prognosis of patients undergoing radical hepatectomy. This scoring system may help clinicians select HCC patients suitable for surgery.
【关键字】:癌,肝细胞;预后;肿瘤标记,生物学
【Key words】:carcinoma, hepatocellular; prognosis; tumor markers, biological
【引证本文】:WEN XJ, YAO MJ, ZHANG L, et al. Value of common laboratory parameters in predicting the prognosis of hepatocellular carcinoma[J]. J Clin Hepatol, 2018, 34(7): 1395-1398. (in Chinese)
文夏杰, 姚明解, 张玲, 等. 实验室常见检测指标对肝细胞癌预后预测价值的思考[J]. 临床肝胆病杂志, 2018, 34(7): 1395-1398.

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