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慢性HBV感染者抗-HBc定量检测的临床意义
Clinical value of anti-HBc quantification for chronic HBV infection
文章发布日期:2018年05月07日  来源:  作者:侯凤琴,王贵强  点击次数:302次  下载次数:91次

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【摘要】:作为国家十二五重大专项课题的成果,抗-HBc定量检测技术已经获得上市批准,有望在临床推广应用。我国学者对抗-HBc的临床意义进行了多方面研究探索,研究结果显示了其在慢性HBV感染自然史、基线抗病毒治疗预测等方面具有较好的应用价值。研究发现抗-HBc与ALT呈明显正相关,与肝脏炎症明显相关,尤其在ALT正常慢性HBV感染者中,抗-HBc可以弥补ALT的不足,对此类患者临床治疗决策的制订具有重要意义。
【Abstract】:Diseases, Peking University First Hospital, Beijing 100034, China) Abstract:As the achivement of a major project during the 12th Five-year Plan Period in China, the technique of anti-HBc quantification has been approved for commercial use and holds promise for wide application in clinical practice. Chinese scholars have explored the clinical significance of anti-HBc in various aspects and found that it has great values in the assessment of natural course of chronic hepatitis B virus (HBV) infection and the baseline prediction of antiviral therapy. Studies have shown that anti-HBc is significantly positively correlated with alanine aminotransferase (ALT) and significantly associated with liver inflammation. In chronic HBV infection patients with a normal ALT level, anti-HBc can be used instead as an indicator, with great significance for the development of therapeutic strategy in such patients.
【关键字】:肝炎, 乙型, 慢性; 肝炎抗体, 乙型; 丙氨酸转氨酶
【Key words】:hepatitis B, chronic; hepatitis B antibodies; alanine transaminase
【引证本文】:HOU FQ, WANG GQ. Clinical value of anti-HBc quantification for chronic HBV infection[J]. J Clin Hepatol, 2018, 34(5): 915-918. (in Chinese) 侯凤琴, 王贵强. 慢性HBV感染者抗-HBc定量检测的临床意义[J]. 临床肝胆病杂志, 2018, 34(5): 915-918.

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