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加强基于大数据药物性肝损伤的科学研究和监管
Strengthening the scientific research and supervision of drug-induced liver injury based on big data
文章发布日期:2018年05月07日  来源:  作者:茅益民  点击次数:148次  下载次数:23次

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【摘要】:药物性肝损伤(DILI)是重要的药源性疾病之一,其临床表型复杂,往往具有不可预测性。由于涉及的药物种类繁多,尤其是复杂的人群异质性,决定了针对DILI的科学研究和监管具有极大的挑战性。目前对于DILI的认知,多来源于国际上长期随访的数据库。然而,DILI领域仍有大量未被满足的临床需求。加强基于大数据DILI的科学研究是更好认知DILI的有效措施,也是科学监管的前提。
【Abstract】:Drug-induced liver injury (DILI) is one of the most important drug-induced diseases and has complex clinical phenotypes, which leads to its unpredictability. The involvement of many types of drugs and complex population heterogeneity pose great challenges to the supervision of scientific research on DILI. Most of our knowledge of DILI comes from the international databases of long-term follow-up. However, there are still many unmet clinical needs in the field of DILI. Strengthening the scientific research on drug-induced liver injury based on big data helps us to understand DILI better and it is the premise for scientific supervision.
【关键字】:药物性肝损伤; 数据库
【Key words】:drug-induced liver injury; database
【引证本文】:
MAO YM. Strengthening the scientific research and supervision of drug-induced liver injury based on big data[J]. J Clin Hepatol, 2018, 34(6): 1166-1168. (in Chinese) 茅益民. 加强基于大数据的药物性肝损伤的科学研究和监管[J]. 临床肝胆病杂志, 2018, 34(6): 1166-1168.

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