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原发性胆汁性胆管炎中西医研究进展
Research advances in integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis
文章发布日期:2018年04月04日  来源:  作者:张玮  点击次数:646次  下载次数:109次

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【摘要】:回顾了原发性胆汁性胆管炎(PBC)的中西医病因病机、中西医治疗的方法和效果,以及笔者在PBC研究中的经验心得。发现PBC发生的风险与环境、遗传、自身免疫、胆管上皮细胞损伤等因素密切相关。中医病因病机分析表明与“虚”“瘀”“郁”“湿”“毒”有关,病因病机关键词是湿热、瘀血、肝郁、气滞、脾气虚、肝气虚、肝肾阴虚,中医证型以湿热蕴结证、肝郁脾虚证、瘀血阻络证、肝肾阴虚证多见。熊去氧胆酸是治疗PBC的首选药物,但仍有多达40%的患者应答不良,中医中药的联合使用对于改善PBC患者生存质量,延长生存期,提高疗效具有不可替代的作用。
【Abstract】:This article reviews the etiology and pathogenesis of primary biliary cholangitis (PBC) based on traditional Chinese and Western medicine, integrated traditional Chinese and Western medicine therapies and their clinical effects, and the author's experience in PBC research. The risk of PBC is closely associated with environmental factors, genetic factors, autoimmunity, and biliary epithelial cell injury. The analysis of etiology based on traditional Chinese medicine (TCM) showed that PBC is associated with "deficiency", "stasis", "depression", "dampness", and "toxin", and the key words of etiology and pathogenesis are damp-heat, blood stasis, stagnation of liver qi, qi stagnation, spleen-qi deficiency, liver-qi deficiency, and liver-kidney yin deficiency. Common TCM syndrome types include damp-heat accumulation, stagnation of liver qi and spleen deficiency, blood stasis obstructing the collaterals, and liver-kidney yin deficiency. Ursodeoxycholic acid is the first-line drug for the treatment of PBC, but 40% of patients have poor response. A combination of traditional Chinese medicine and Western medicine plays an important role in improving quality of life, prolonging survival time, and improving the clinical outcome of patients with PBC.
【关键字】:肝硬化, 胆汁性; 中西医结合; 中医病因和病机
【Key words】:liver cirrhosis, biliary; integrated TCM WM; etiol factor & pathog TCM
【引证本文】:ZHANG W. Research advances in integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis[J]. J Clin Hepatol, 2018, 34(4): 698-703. (in Chinese)
张玮. 原发性胆汁性胆管炎中西医研究进展[J]. 临床肝胆病杂志, 2018, 34(4): 698-703.

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