首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 3期肝胆胰疾病的内镜诊疗 => 其他 =>近5年我国药物性肝损伤患者临..
近5年我国药物性肝损伤患者临床特征分析
Clinical features of patients with drug-induced liver injury in China in the last five years
文章发布日期:2018年02月07日  来源:  作者:张艳梅,孙文静,文良志,等  点击次数:372次  下载次数:64次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的总结分析我国近5年来文献报道的药物性肝损伤(DILI)患者的临床特征。方法检索2012年1月-2016年12月我国DILI相关原始病例报道,并从中纳入202篇相关文献,共计26 015例DILI患者。总结DILI的性别、年龄及地域分布、致病药物、临床特征及预后情况。计数资料以率或构成比描述。结果26 015例DILI患者中,男12 885例(49.53%),女13 130例(5047%),平均46.86岁。排列前5位的致病药物分别为中药(34.68%)、抗结核药(15.81%)、抗微生物药(12.04%)、抗肿瘤药(9.09%)、解热镇痛药(6.17%)。临床表现主要为乏力(50.37%)、黄疸(52.68%)、纳差(43.59%)。158篇文献记录了19 994例患者DILl的分型,其中肝细胞型占58.84%、胆汁淤积型占21.79%、混合型占19.37%。肝活组织检查在诊断DILI中有一定价值。停用可疑药物,给予抗炎、保肝等综合治疗是DILI的主要治疗方式。179篇文献记录了22 030例患者的预后信息,其中治愈11 159例(5065%)、好转8742例(39.68%)、无效1176例(5.34%)、死亡353例(1.60%)。结论国内文献报道DILI男女比例相当,中药引起的DILI最为常见,损伤类型以肝细胞型居多,治愈及好转率90.34%,患者大多预后良好。
【Abstract】:ObjectiveTo investigate the clinical features of patients with drug-induced liver injury (DILI) in China in the last five years. MethodsRelated databases were searched for original case reports on DILI in China published from January 2012 to December 2017, and a total of 202 articles with 26 015 DILI patients were included in this analysis. Sex, age, geographical distribution, causative drugs, clinical features, and prognosis were summarized and analyzed. Categorical data were expressed as rate (%) or constituent ratio. ResultsOf all 26 015 patients, 12 885 (49.53%) were male and 13 130 (50.47%) were female, with a mean age of 46.86 years. The five most common causative drugs were traditional Chinese medicine (TCM) (34.68%), anti-tubercular agents (15.81%), anti-microbial drugs (1204%), antitumor drugs (9.09%), and analgesic-antipyretic drugs (6.17%). Major clinical manifestations included fatigue (5037%), jaundice (52.68%), and poor appetite (43.59%). A total of 158 articles recorded the typing of 19994 DILI patients, among whom 58.84% had the hepatocellular type, 21.79% had the cholestasis type, and 19.37% had the mixed type. Liver biopsy had a certain value in the diagnosis of DILI. Major therapies for DILI included withdrawal of suspected drugs, anti-inflammatory treatment, and liver protection. A total of 179 articles reported the prognosis of 22 030 patients, among whom 11 159 (50.65%) were cured, 8742 (39.68%) were improved, 1176 (5.34%) had no response, and 353 patients (1.60%) died. ConclusionThere is a similar incidence rate of DILI between male and female populations. TCM is the most common causative drugs for DILI. The hepatocellular type is the most common clinical type. The cured and improved rate is as high as 90.34%, and most patients have good prognosis.
【关键字】:药物性肝损伤; MEDLARS; 中国
【Key words】:drug-induced liver injury;MEDLARS;China
【引证本文】:ZHANG YM, SUN WJ, WEN LZ, et al. Clinical features of patients with drug-induced liver injury in China in the last five years[J]. J Clin Hepatol, 2018, 34(3): 562-566. (in Chinese)
张艳梅, 孙文静, 文良志, 等. 近5年我国药物性肝损伤患者临床特征分析[J]. 临床肝胆病杂志, 2018, 34(3): 562-566.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号