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肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展
Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway
文章发布日期:2017年12月09日  来源:  作者:鞠迪,李京涛,韩曼,等  点击次数:289次  下载次数:67次

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【摘要】:肝硬化-肝细胞癌癌前病变的恶性转变导致肝癌的形成。肝星状细胞(HSC)通过TGFβ1-PI3K/AKT信号通路影响肝细胞癌癌前病变细胞产生、肝纤维化微环境的形成以及两者相互作用。了解肝硬化-肝细胞癌癌前病变的恶变机制与HSC和TGFβ1-PI3K/AKT信号通路的关系,将有助于深入了解肝细胞癌的发生机制。通过调控HSC或干预TGFβ1-PI3K/AKT信号通路可阻止甚至或逆转肝硬化向肝细胞癌的进展,为预防和干预肝细胞癌发生提供新的思路和治疗靶点。
【Abstract】:The malignant transformation of the precancerous lesions of liver cirrhosis and hepatocellular carcinoma (HCC) leads to the formation of liver cancer. Hepatic stellate cells (HSCs) play a role in the production of cells in precancerous lesions of HCC, the formation of hepatic fibrosis microenvironment, and the interaction between them via the TGFβ1-PI3K/AKT signaling pathway. An understanding of the mechanism for the malignant transformation of the precancerous lesions of liver cirrhosis and HCC and the association between HSCs and the TGFβ1-PI3K/AKT signaling pathway helps to investigate the pathogenesis of HCC. Regulation of HSCs or intervention of the TGFβ1-PI3K/AKT signaling pathway can inhibit or reverse the progression of liver cirrhosis to HCC, which provides new thoughts and therapeutic targets for prevention and intervention of the development of HCC.
【关键字】:肝硬化;癌,肝细胞;癌前状态;肝星状细胞;信号传导;综述
【Key words】:liver cirrhosis; carcinoma, hepatocellular; precancerous conditions; hepatic stellate cell; signal transduction; review
【引证本文】:JU D, LI JT, HAN M, et al. Research advances in the influence of hepatic stellate cells on precancerous lesions of liver cirrhosis and hepatocellular carcinoma via the TGFβ1-PI3K/AKT signaling pathway[J]. J Clin Hepatol, 2018, 34(1): 192-194. (in Chinese)
鞠迪, 李京涛, 韩曼, 等. 肝星状细胞通过TGFβ1-PI3K/AKT信号通路影响肝硬化-肝细胞癌癌前病变的研究进展[J]. 临床肝胆病杂志, 2018, 34(1): 192-194.

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